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MODULATING BONE MORPHOGENIC PROTEIN (BMP) SIGNALING IN THE TREATMENT OF ALZHEIMER’S DISEASE

MODULATING BONE MORPHOGENIC PROTEIN (BMP) SIGNALING IN THE TREATMENT OF ALZHEIMER’S DISEASE Researchers at Stanford University have described a novel therapeutic target for Alzheimer’s disease. Alzheimer’s disease (AD) presents a large public health burden, effecting an estimated 5.5 million people in the United States and occurring...

Published: 4/13/2023 | Inventor(s): Michael Clarke, Jane Antony, Maddalena Adorno, Elizabeth Chen, Benedetta n di Robilant, Felicia Reinitz

Keywords(s): Alzheimer’s Disease, BMP, Inhibitor, Neural Progenitor, Stem Cell

Category(s): Technology Classifications > Biology

Novel ACRV1/ALK2 Inhibitors and Methods for Inhibiting BMP Signaling for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

This technology includes the identification and use of novel ACRV1/ALK2 inhibitors for the treatment of fibrodysplasia ossificans progressiva (FOP), an autosomal-dominant rare disease that affects one person in every 1-2 million. FOP is characterized by malformation of the great (big) toes during embryonic development and by progressive heterotopic...

Published: 10/28/2024 | Inventor(s): Jian-kang Jiang, Khalida Shamim, Philip Sanderson, Wei Zheng, Xiuli Huang, Gregory Tawa, Asaf Alimardanov, Arthur Lee, Junfeng Huang, Wenwei Huang

Keywords(s): ALK2, BMP, INHIBITING, Inhibitors, Methods, Novel, SIGNALING, VGXXXX, WIXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, Application > Research Materials

COMPOSITIONS AND METHODS FOR MODULATING LEFTY AND BMP PROTEINS

COMPOSITIONS AND METHODS FOR MODULATING LEFTY AND BMP PROTEINS Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have surprisingly found that LEFTY1 suppresses not only the SMAD2/3 signaling pathway (a pathway activated by Nodal signaling) but also the SMAD1/5/8 signaling pathway (a pathway activated by BMP proteins, including...

Published: 9/30/2024 | Inventor(s): Michael Clarke, Neethan Lobo, Maider Ugalde

Keywords(s): BMP, Breast Cancer, Cancer, LEFTY, Neoplasm, TGF-β Superfamily

Category(s): Technology Classifications > Biology