Search Results - inflammatory+bowel+disease+1

5 Results Sort By:
Caspase Inhibitors Useful for the Study of Autoimmune or Inflammatory Diseases
Novel and potent caspase 1 inhibitors are available for licensing. In particular, this technology discloses potent and selective caspase 1 inhibitors that target the active site of the enzyme. Caspase 1 is known to play a pro-inflammatory role in numerous autoimmune and inflammatory diseases and therefore represents an excellent target for treatment...
Published: 10/28/2024   |   Inventor(s): Matthew Boxer, Craig Thomas
Keywords(s): 1, Amyotrophic lateral sclerosis, Amyotrophic lateral sclerosis 1; Amyotrophic lateral scleros, Amyotrophic lateral sclerosis 6, Caspase, IB3XXX, IBXXXX, Inflammatory bowel disease 1, inhibitor, IXXXXX, Lou Gehrig's disease, Patent Category - Chemistry
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Immunology
Muramyl Dipeptide as a Therapeutic Agent for Inflammation
The nucleotide-binding oligomerization domain 2 (NOD2) protein plays a key role in innate immunity as a sensor of muramyl dipeptide (MDP), a breakdown product of bacterial peptidoglycan. Bacterial peptidoglycan promotes the innate immune response through the activation of Toll-like receptor 2 (TLR2), which ultimately provokes inflammation. Activation...
Published: 10/28/2024   |   Inventor(s): Warren Strober
Keywords(s): Autoimmune, AUTOIMMUNE DISEASE, Autoimmune disorder, Autoimmunity, BBXXXX, BCXXXX, BOWEL, Crohn disease; Inflammatory bowel disease 1, Crohn's disease, Dipeptide, IB3XXX, IBD, IBXXXX, IL-12, Inflammation, INFLAMMATORY, inflammatory bowel disease, Inflammatory bowel disease 1, inflammatory disease, INTERLEUKIN, INTERLEUKIN-12, IRF4, IXXXXX, MDP, Muramyl, NOD2, peptidoglycan, TLR, TLR2, Toll-like, Toll-like receptors, Ulcerative Colitis
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics
Treatment and Prevention of Inflammatory Bowel Disease (IBD) using Mutant and Chimeric IL-13 Molecules
Ulcerative colitis (UC) is a chronic inflammatory disease of the colorectum and affects approximately 400,000 people in the United States. The cause of UC is not known, although an abnormal immunological response to bacterial antigens in the gut microflora is thought to be involved. Present treatments for UC include anti-inflammatory therapy using...
Published: 10/28/2024   |   Inventor(s): Warren Strober, Peter Mannon, Jan Preiss, Raj Puri, Koji Kawakami, Stefan Fichtner-Feigl, Atsushi Kitani
Keywords(s): Crohn disease; Inflammatory bowel disease 1, IB3XXX, IB6XXX, IBXXXX, Inflammatory bowel disease 1, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Immunology, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Reproductive Health
The Use of an Inducible Plasmid Vector Encoding for Active TGF-beta for the Treatment of Autoimmune Diseases
This application describes a composition and method for treating inflammatory bowel disease or other autoimmune diseases. The composition utilizes a vector which contains a first promoter which controls the expression of a regulatory transcription factor and a second inducible promoter which controls the expression of the gene of interest. The preferred...
Published: 10/28/2024   |   Inventor(s): Warren Strober
Keywords(s): CB3AXX, CB3BXX, CB3XXX, CBXXXX, CXXXXX, GB2A1X, GB2A3X, GB2AXX, GB2BXX, GB2CXX, GB2XXX, GBXXXX, GXXXXX, IB3XXX, IBXXXX, Inflammatory bowel disease 1, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Immunology
Peptides for Treatment of Tumor Necrosis Factor alpha Mediated Inflammatory Disease
Tumor Necrosis Factor alpha (TNF-alpha) is a multifunctional cytokine that mediates inflammation, immune regulation, and cellular proliferation. This cytokine is converted to its active form by TNF-alpha converting enzyme (TACE). Pathological increases in TNF-alpha activity have been associated with a wide variety of inflammatory diseases, including...
Published: 10/28/2024   |   Inventor(s): Stewart Levine
Keywords(s): Crohn disease, Demyelinating diseases, IB3XXX, IBXXXX, Inflammatory bowel disease 1, IXXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Immunology