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Reference Number:1658 Background In recent times, stents have revolutionised the treatment of coronary artery disease, which causes narrowing of the coronary arteries due to the formation of lipid-filled plaques. The stent is threaded into the coronary artery, where it is expanded, opening the artery, and providing a scaffold to support the lumen....

Published: 1/21/2011 | Inventor(s): Patricia Connolly, Laurie Shedden, Simon Kennedy, Roger Wadsworth

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Category(s): Medical Devices

Drug Eluting Stent for High Risk Patients

Reference Number:0204 Background Stent implantation is a highly effective treatment for restoring blood flow through an atherosclerotic artery; however restenosis (a re-narrowing of the diseased artery) occurs in a significant proportion of patients. Drug-eluting stents have been developed to limit restenosis and although they represent a major...

Published: 2/1/2011 | Inventor(s): Roger Wadsworth, Cherry Wainwright, Nigel Pyne, Susan Pyne, Lorraine Work

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Category(s): Drug Discovery

Selectively enhancing nitric oxide activity in damaged blood vessels

Reference Number: 1591 Background Many drugs are aimed at enhancing the therapeutic potential of nitric oxide (NO) in the cardiovascular system. These generally lack selectivity, hence there is a need to treat diseased tissues more specifically in order to restore their function. This can be achieved by boosting the natural enzymatic synthesis of...

Published: 2/21/2014 | Inventor(s): Roger Wadsworth, Colin Suckling, Colin Gibson

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Category(s): Drug Discovery