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Novel Methods for Reducing Inflammation and Treating Diseases such as Parkinson's and Alzheimer's Disease
Microglia activation leads to inflammation mediated dopaminergic degeneration in the brain of patients with Parkinson and Alzheimer's Disease. Thus Identification of drugs that reduce microglia activation could prevent or reverse neuronal degeneration in these diseases and other degenerative CNS disorders.
This invention describes small-peptide and...
Published: 10/28/2024
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Inventor(s): Liya Qin, Guorong Li, MIchelle Block, Wei Zhang, Po-See Chen, Giia-Shuen Peng, Jau-Shyong Hong
Keywords(s): Alzheimer disease 1, Alzheimer disease 3, Alzheimer disease 4, Alzheimer disease type 1, Alzheimer disease type 4, Alzheimer disease, familial, type 3, BBXXXX, Discovery, DOSE, femto-molar, IB3XXX, IBXXXX, Inflammation-associated, IXXXXX, Listed LPM Greene as of 4/15/2015, NB1BXX, NBXXXX, NEURODEGENERATIVE, NXXXXX, Parkinson disease 2, Parkinson disease 3, Parkinson disease 9, Parkinson disease, juvenile, autosomal recessive, Parkinson's, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Prevention, therapeutic, therapeutics, Ultra-low, VEXXXX, WJXXXX, WKXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Neurology, TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials
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Novel Compounds in Treating Autophagy-Related Pathologies
Project IDs: D2015-09 and D2016-81
Background:
Autophagy is a self-degradation process of cellular organelles that helps defend against metabolic stress, maintain metabolic equilibrium, arbitrate cell fate decisions, and safeguard genomic stability. Deficient autophagy has been associated with over 100 diseases, and experimental enhancement of autophagy...
Published: 5/9/2024
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Inventor(s): Kenneth Hensley, Travis Denton
Keywords(s): ALS, Alzheimer's, Autophagy, Lanthionine Ketimine, Parkinson's
Category(s): Neuroscience
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Repurposing AKT Inhibitors for the Treatment of Protein Misfolding and Protein Trafficking Diseases
WSU researchers have generated a reagent to understand the degenerative processes occurring in Pelizaeus‑Merzbacher disease (PMD) and to study the intracellular signaling that occurs because of these diseased processes. They have deduced that the use of AKT inhibitors may reduce disease severity in patients with a wide range of degenerative diseases.
Background...
Published: 2/8/2022
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Inventor(s): Alexander Gow, Cherie Southwood
Keywords(s): Alzheimer's Disease, Anti-cancer, Neuro-disorders, Parkinson's
Category(s): Life Science, Neurological disorders, Therapeutics, Diseases
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CNS Compounds Specific for the Monoamine Transporter Systems
This invention includes novel compounds that have neuropharmacological activity with the dopamine receptor and the method of using them to treat central nervous system disorders.
Background & Unmet Need:
The dopamine transporter (DAT) plays an important role in processes of the central nervous system. In cocaine addiction, binding of cocaine...
Published: 2/8/2022
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Inventor(s): Aloke Dutta
Keywords(s): Addiction Treatment, Antidepressants, Neuroscience, Parkinson's
Category(s): Therapeutics, Life Science, Diseases, Neurological disorders
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