Search Results - genome+editing

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Mice with humanized telomere homeostasis

Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...

Published: 10/8/2024 | Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng

Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase

Category(s): Technologies > Health & Well-being > Biotechnology

PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME

PHAGE-MEDIATED DELIVERY OF GENES TO GUT MICROBIOME Researchers at UCSF have developed methods to engineer bacteriophage for gene delivery to gut microbiome. There is broad interest in the influence that the gut microbiome has on host health and disease. Mechanistic insights into the role of the human gut microbiome in the predisposition to and...

Published: 3/17/2023 | Inventor(s): Kathy Lam, Peter Spanogiannopoulos, Peter Turnbaugh

Keywords(s): Bacterial Pathogenesis, CRISPR, Genome Editing

Category(s): Technology Classifications > Biology

Germline Ablation in Goats

Unmet Need: Accurate and dependable breeding of desired traits While livestock all over the world exhibit a variety of traits that allow them to survive in different environments, they don’t always have other qualities breeders deem to be desirable, like high quality meat or growth potential. In the past, people would bring in a male –...

Published: 10/8/2024 | Inventor(s): Jon Oatley, Irina Polejaeva

Keywords(s): Agriculture, Animal Research, Genome editing, Germline Ablation, Nanos2, Sperm, Spermatgonial stem cell

Category(s): Products, Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Veterinary, Technologies > Food & Nutrition > Agriculture and Plant Sciences

BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS

BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS Researchers at Stanford and the Chan Zuckerberg Biohub have developed a methodology to monitor cell expansion and differentiation following targeted genomic modification. Targeted DNA correction of disease-causing mutations offers promise in the treatment of genetic diseases. Following targeted...

Published: 3/17/2023 | Inventor(s): Daniel Dever, Rajiv Sharma, Matthew Porteus, Ravindra Majeti, Joab Camarena, Thomas Koehnke

Keywords(s): Blood, Cas9, CRISPR, Genome Editing, Genome Integration, Nuclease

Category(s): Technology Classifications > Biology

DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT

DISCOVERY OF A HIGHLY THERMOSTABLE CAS9 VARIANT Researchers at Stanford and the Chan Zuckerberg Biohub have discovered a Cas9 protein variant from Ignavibacterium that is thermostable at elevated temperatures. The application of genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated...

Published: 3/17/2023 | Inventor(s): Stephen Quake, Stephanie Schmidt, Feiqiao Yu, Paul Blainey, Andrew May

Keywords(s): Cas9, CRISPR, Genome Editing, Nuclease, Themostable

Category(s): Technology Classifications > Biology