Search Results - angiogenesis

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Assay to Screen Anti-metastatic Drugs
Abstract: Scientists at the NCI developed a research tool, a murine cell line model (JygMC(A)) with a reporter construct, of spontaneous metastatic mammary carcinoma that resembles the human breast cancer metastatic process in a triple negative mammary tumor. The assay is useful for screening compounds that specifically inhibit pathways involved in...
Published: 8/13/2024   |   Inventor(s): Nadia Castro, David Salomon, Frank Cuttitta
Keywords(s): ANGIOGENESIS, Cell line, Metastasis, Triple Negative Breast Cancer, tumorigenesis
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Research Materials
Angiogenesis-Based Cancer Therapeutic
Abstract: Vascular Endothelial Growth Factor-A (VEGF-A) is an angiogenic agent that drives blood vessel formation in solid tumors and other diseases, such as macular degeneration and diabetic retinopathy. Several therapies that target the ability of VEGF to stimulate angiogenesis have been approved. These therapies regulate VEGF-A activity by binding...
Published: 4/8/2024   |   Inventor(s): Donald Bottaro, Fabiola Cecchi
Keywords(s): ANGIOGENESIS, CHEMOTHERAPY, Diabetic Retinopathy, FLT-1, Heparin sulfate proteoglycan, Hepatocyte growth factor (HGF), KDR/FLK-1, Macular degeneration, VEGF-A
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Bottom-Up Tissue Regeneration Scaffold That Rebuilds Tissue Where It Is Needed
Supports Layered Cell Regrowth, Tissue Repair, Fluid Perfusion and Wound Healing to Replace Injured Bone, Muscle and Skin TissuesThis tissue regeneration platform facilitates the layered regrowth of cells to heal traumatic wounds and other injuries by growing bone, muscle, and skin tissues right where they are needed. Regenerative medicine, in which...
Published: 6/27/2021   |   Inventor(s): Adam Katz
Keywords(s): Angiogenesis, diffusion, Engineering, microfluidics, regeneration, stem cells, Tissue, Tissue Engineering
Category(s): Technology Classifications > Engineering, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Medical Devices