Search Results - fibrosis

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Self-delivery USP10 siRNA to promote regenerative healing-new IP

This technology employs an engineered self-delivering siRNA to selectively reduce USP10 protein levels in tissues, thereby promoting regenerative healing and suppressing pathological scarring. Preclinical studies in the eye demonstrate a favorable safety profile and robust efficacy, supporting the potential of this approach for treating fibrotic disease...

Published: 1/29/2026 | Inventor(s): Audrey Bernstein, Sean McCauley, Alexey Wolfson, Tere Williams

Keywords(s): fibrosis, opthalmology, scarring, siRNA, skin diseases, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Campus > Upstate Medical University

Self-Deliverable siRNA to Prevent Corneal Scarring

Targeted gene silencing technology promotes corneal wound healing. Background: Ocular scarring after surgery, trauma, or infection leads to vision loss and blindness. Blindness due to corneal scarring can currently only be resolved by transplantation, necessitating new approaches in regenerative wound healing in the eye. Technology Overview:...

Published: 1/30/2026 | Inventor(s): Audrey Bernstein

Keywords(s): cornea, fibrosis, integrin, myofibroblast, scarring, TAF, wound healing

Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Healthcare, Campus > Upstate Medical University

Targeting TANGO-1 as a Treatment for Fibrosis (TARTF)

Collagen secretion inhibition in cell and mouse models of fibrosis Compounds that inhibit the formation of the collagen endoplasmic reticulum (ER)-exit machinery in fibroblasts reducing collagen secretion. They can be used for treating fibrotic diseases by targeting the key, common pathological issue, collagen secretion. Technology: Fibrosis underpins...

Published: 11/11/2024 | Inventor(s): Vivek Malhotra, Ishier Raote, Thomas Krieg, Beate Eckes, Ines Neundorf

Keywords(s): Dermatology, Fibrosis, Respiratory Tract Diseases

Category(s): Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)

Methods for Treating or Ameliorating Fibrosis by Inhibiting the Interaction between IL-21 Receptor (IL-21R) and IL-21

This invention includes methods for treating or ameliorating fibrosis by inhibiting the interaction between IL-21 Receptor (IL-21R) and IL-21 using either anti-IL-21R monoclonal antibodies (or binding fragments of anti-IL-21R mAbs), anti-IL-21 monoclonal antibodies (or binding fragments of anti-IL-21 mAbs) or soluble IL-21R (or binding fragments of...

Published: 2/6/2026 | Inventor(s): Thomas Wynn

Keywords(s): Asbestosis, CB1AXX, CB1XXX, CB6XXX, CBXXXX, CXXXXX, Cystic fibrosis, DEFICIENCY, FIBROSIS, Hepatitis A, Hepatitis D, Hepatitis E, IL-21, Immunity, Inflammmation, Patent Category - Biotechnology, RECEPTOR, REDUCES, SCHISTOSOMIASIS, Schistosomiasis (Schistosoma sp.), Scleroderma, Scleroderma, systemic, Tissue, TYPE-2

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics

Allosteric Inhibitors of HIPK2 for the Treatment of Renal Fibrosis

Thank you for your interest in this technology. Please see our technology brief here: https://app.in-part.com/articles/RQx7n6Ja7ZeM

Published: 10/2/2025 | Inventor(s): John Cijiang He

Keywords(s): Fibrosis, Nephrology

Category(s): Therapeutic

Antibodies Targeting CB1/AT1R or CB1/A2aR Heteromers to Treat Liver Fibrosis

Thank you for your interest in this technology. Please see our technology brief here: https://app.in-part.com/articles/9y5gxRj67BLK

Published: 1/9/2025 | Inventor(s): Lakshmi Arehole Devi, Raphael Rozenfeld

Keywords(s): Fibrosis, Liver Disease

Category(s): Therapeutic