Search Results - immunity

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Cancer Therapeutic based on Stimulation of Natural Killer T-cell Anti-tumor Activity
Abstract: Natural killer T cells (NKT) are a unique lymphocyte population that has T-cell and NK cell functional properties in order to rapidly elicit an immune response.  alpha-galactosylceramide (alpha-GalCer) is a potent NKT stimulator and induces of IFN-gamma release to promote immunity against tumors and infectious agents.  Humans have natural...
Published: 4/8/2024   |   Inventor(s): Masaki Terabe, Jessica O'Konek, Petr Illarionov, Jay Berzofsky, Gurdyal Besra
Keywords(s): ANTIBODY, Immunity, NKT activity
Category(s): Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Methods for Treating or Ameliorating Fibrosis by Inhibiting the Interaction between IL-21 Receptor (IL-21R) and IL-21
This invention includes methods for treating or ameliorating fibrosis by inhibiting the interaction between IL-21 Receptor (IL-21R) and IL-21 using either anti-IL-21R monoclonal antibodies (or binding fragments of anti-IL-21R mAbs), anti-IL-21 monoclonal antibodies (or binding fragments of anti-IL-21 mAbs) or soluble IL-21R (or binding fragments of...
Published: 10/28/2024   |   Inventor(s): Thomas Wynn
Keywords(s): Asbestosis, CB1AXX, CB1XXX, CB6XXX, CBXXXX, CXXXXX, Cystic fibrosis, DEFICIENCY, FIBROSIS, Hepatitis A, Hepatitis D, Hepatitis E, IL-21, Immunity, Inflammmation, Patent Category - Biotechnology, RECEPTOR, REDUCES, SCHISTOSOMIASIS, Schistosomiasis (Schistosoma sp.), Scleroderma, Scleroderma, systemic, Tissue, TYPE-2
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics
Enhanced Immune Response Against Influenza Virus by Priming with a DNA-based Vaccine
Available for licensing and commercial development are compositions and methods for enhancing an immune response to influenza viruses by priming with DNA-based vaccines encoding influenza proteins. The priming compositions contain DNA constructs with inserted nucleic acids encoding influenza virus hemagglutinin (HA) or an epitope-bearing domain thereof,...
Published: 8/15/2024   |   Inventor(s): Chih-jen Wei, Gary Nabel
Keywords(s): BOOSTING, DC5BXX, DC5XXX, DCXXXX, DNA constructs, DNA vaccine, DXXXXX, H1N1, H5N1, HEMAGGLUTININ, Immunity, INACTIVATED, INFLUENZA, Method, Patent Category - Biotechnology, Vaccine
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
PSM Peptides as Vaccine Targets Against Methicillin-Resistant Staphylococcus aureus
Available for licensing and commercial development are compositions and methods for the treatment and inhibition of Methicillin-resistant Staphylococcus aureus (MRSA), a dangerous human pathogen. The invention concerns immunogenic peptides that can be used to induce protective immunity against MRSA, including phenol-soluble modulin (PSM) peptides. In...
Published: 10/28/2024   |   Inventor(s): Rong Wang, Michael Otto
Keywords(s): Against, ANTIBIOTIC, AUREUS, CA-MRSA, DB3XXX, DBXXXX, DC4XXX, DCXXXX, DXXXXX, fasciitis, Gene, GenePeptides, Immunity, Immunogenic, Methicillin-resistant, MRSA, necrotizing, necrotizing fasciitis, Peptides, PMS, PSM, Staphloccus, STAPHYLOCOCCAL, Staphylococcus, Targets, Vaccine
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Infectious Disease
Vaccines Comprising Sand Fly Salivary Proteins for Control of Leishmania Infection
This invention relates to the use of several peptides from the salivary glands of various sand fly species for the control of leishmania infection. Many of these peptides were shown to be effective in eliciting potent immune responses in animal models and are excellent candidates for the development of vaccines against the disease. A vaccine comprising...
Published: 10/28/2024   |   Inventor(s): Jesus Valenzuela
Keywords(s): Adn, America, ARIASI, Cellular, Chagase, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, DDXXXX, Dogs, DXXXXX, Efficient, ELICIT, Fly, Identification, IFN-gamma, Immunity, Infantum, KILLING, Latin, LEISHMANIA, LEISHMANIASIS, Leishmaniasis (Leishmania sp.), Listed LPM Stansberry as of 4/15/2015, LJL143, LJM17, Longipalpis, Lutzomyiz, Method, P., Patent Category - Biotechnology, PERNICIOSUS, POLYPEPTIDES, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, production, proteins, RESULTING, Salivary, SAND, That, Vector, Visceral, WIPO Re:search
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease