Search Results - stem+cells

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Method for Reproducible Differentiation of Clinical Grade Retinal Pigment Epithelium Cells
Abstract: The retinal pigment epithelium (RPE) is a cell monolayer with specialized functions crucial to maintaining the metabolic environment and chemistry of the sub-retinal and choroidal layers in the eye. Damage or disease causing RPE cell loss leads to progressive photoreceptor damage and impaired vision. Loss of RPE is observed in many of the...
Published: 4/8/2024   |   Inventor(s): Kapil Bharti
Keywords(s): Age Related Macular Degeneration, AMD, Best Disease, Bharti, Human Induced Pluripotent Stem Cells, Human Retinal Pigment Epithelial Cells, IPSCS, National Eye Institute, National Institute of Arthritis and Muscoskeletal and Skin D, NEI, NIAMS, Photoreceptor, Retinal Degenerative Diseases, RPE, STEM CELLS, Vision Loss
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Licensing
Novel Methods for Generating Retinal Pigment Epithelium Cells from Induced Pluripotent Stem Cells
Abstract: The retinal pigment epithelial cells (RPE) make up a polarized monolayer in the vertebrate eye that separates the neural retina from the choroid, and performs a crucial role in retinal physiology by forming a blood-retinal barrier and closely interacting with photoreceptors to maintain visual function.  Many ophthalmic diseases, such as age-related...
Published: 4/8/2024   |   Inventor(s): Kapil Bharti, Kapil Bharti, Janine Davis, Sheldon Miller, Arvydas Maminishkis, Marc Ferrer-Alegre
Keywords(s): Age-related Macular Degeneration, AMD, DIFFERENTIATION, retinal pigment epithelial cells, STEM CELLS
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat
Air-foil Shaped Tissue Harvester for Pluripotent Stem Cells to Proliferate and Undergo Differentiation
Utilizes Mechanochemical Signaling and a Textured Surface to Generate a Variety of Cells for Various Medical TherapiesThis tissue harvester creates an active apparatus upon which amniotic, progenitor, mesenchymal, and embryonic stem cells can rapidly proliferate and mature into more distinct forms and functions due to the versatile airfoil shape of...
Published: 6/20/2022   |   Inventor(s): Mina-Elraheb Hanna, Juan Nino
Keywords(s): adult stem cells, Amniotic, Differentiation, Embryonic Stem Cells, fluid flow, mechanobiology, mechanochemical signaling, mechanotranduction, Mesenchymal, Mesenchymal Stem Cells, progenitor, shear force/stress, stem cells, substrate stiffness, surface roughness, tissue differentiation, tissue harvesting
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Medical Devices > Consumable
Efficient and Non-Genotoxic Gene Transfer System for Stem Cells
Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents;...
Published: 5/22/2024   |   Inventor(s): Arash Hatefi, Xuguang Chen, Alireza Nomani
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
New Cell Therapy Device for Isolating Cells and Exosomes
GMP-grade closed-system clinical cell therapy device for isolation and delivery of cells and exosomes. Invention Summary: Regenerative medicine research has become an important field of study due to the ability of regenerating cells to restore a wide variety of cell types. Regenerating cells can be isolated from multiple sources and can be used...
Published: 8/31/2022   |   Inventor(s): Hatem Sabaawy
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
New Cell Therapy Strategy for Treatment of Spinal Cord Injuries
Cell therapy strategy for spinal cord injuries and regenerative diseases. Invention Summary: Spinal cord injuries (SCI) are damages to the spinal cord neural tissues that cause sensory loss and motor paralysis. SCI patients have no options for curative therapy. Thus, a mild contusion to the spinal cord results in massive neuronal and glial cell...
Published: 8/31/2022   |   Inventor(s): Hatem Sabaawy
Keywords(s): Spinal Cord, Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Personalized and Timed Release of Biomolecules
Invention Summary: Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections. Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics...
Published: 10/12/2022   |   Inventor(s): Biju Parekkadan, Alexandra Burr, Alfred Tamayo
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Cell Therapy, Technology Classifications > Gene Therapy
Self-oxygen generating biomaterials for large tissue engineering
Organ transplantation continues to increase, with 34,770 transplants performed in the US in 2017. Currently, organ transplantation is limited by donor dependence, high costs, and, long-term use of immunosuppressive medications which, in turn, correlates with significant morbidity and mortality. To overcome these limitations, tissue engineering and transplantation...
Published: 3/5/2024   |   Inventor(s): Iman Noshadi
Keywords(s): Biomaterials, Electrolyte, Energy Storage, Hydrogels, Oxygenation, Regenerative Medicine, Scaffold, Stem Cells, Tissue Engineering , Transplant
Category(s): Human Health Care > Biomaterials
A novel sealant device that aids in stem cell localization in the treatment of lower back pain
TechnologyOne of the major causes of lower back pain is intervertebral disc (IVD) degeneration also known as lumbar degenerative disc disease which often leads to disk herniation. IVD results from the dehydration of the central nucleus pulposus (NP) which ultimately alters the biomechanics of the disc and eventually causes tears to form in the peripheral...
Published: 2/7/2024   |   Inventor(s): Andrea Vernengo, Thomas Christiani, Cristina Iftode, Jennifer Kadlowec
Keywords(s): Back Pain, Biomaterials, Hydrogels, Implant, Polymers, Stem Cells, Tissue Engineering
Category(s): Human Health Care > Biomaterials, Human Health Care > Medical Devices, Human Health Care > Therapeutics
Bottom-Up Tissue Regeneration Scaffold That Rebuilds Tissue Where It Is Needed
Supports Layered Cell Regrowth, Tissue Repair, Fluid Perfusion and Wound Healing to Replace Injured Bone, Muscle and Skin TissuesThis tissue regeneration platform facilitates the layered regrowth of cells to heal traumatic wounds and other injuries by growing bone, muscle, and skin tissues right where they are needed. Regenerative medicine, in which...
Published: 6/27/2021   |   Inventor(s): Adam Katz
Keywords(s): Angiogenesis, diffusion, Engineering, microfluidics, regeneration, stem cells, Tissue, Tissue Engineering
Category(s): Technology Classifications > Engineering, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Medical Devices
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