Search Results - mehdi+nikkhah

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Tissue Microenvironment Microfluidic Devices

Recent advances in manufacturing techniques have enabled the development of platforms and devices to study tissues and cells within well defined 3D microenvironments. Current devices have many limitations, however, because they are primarily made with polydimethylsiloxane (PDMS). PDMS is soft, so it is difficult to create reliable fluid connections...

Published: 1/4/2024 | Inventor(s): Mehdi Nikkhah, Shaun Wootten, Ronin-Mae Komarnisky

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Category(s): Bioanalytical Assays, Chemistries & Devices, Biomaterials, Life Science (All LS Techs), Advanced Materials/Nanotechnology

High-throughput Microfluidics Tumor-Stroma Platform

Cancer is a leading cause of death around the world, accounting for nearly 10 million deaths in 2020 according to the WHO. Common cancer therapies, particularly chemotherapeutics, tend to be expensive with a relatively low rate of success. Further, they take a toll on the patient’s body. Personalized therapeutics, while more successful, require...

Published: 2/23/2023 | Inventor(s): Mehdi Nikkhah, Ouse Sheblak

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Category(s): Cancer Therapeutics, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Advanced Materials/Nanotechnology

Electrically Conductive Cardiac Microtissues

There are an estimated 23 million people with heart failure worldwide, with 1-year mortality rate of 30% following onset. Loss of cardiomyocytes (CMs) from myocardial infarction results in remodeling and abnormal stress distribution throughout the tissue, leading to increased morbidity. Regenerative medicine and tissue engineering strategies offer promising...

Published: 2/23/2023 | Inventor(s): Mehdi Nikkhah, Ali Navaei, Raymond Migrino

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Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics

Conductive and Biocompatible Electrodes that Prevent Fibrotic Capsule Formation

Implanted electrode leads deliver a current from a powered device to tissue that requires electrical stimulation. A host of complications can arise from surgical implantation of electrode leads; however, foreign body responses and the rapid formation of a fibrotic capsule around the lead are the most frequent. Even with surface coating modifications...

Published: 2/23/2023 | Inventor(s): Mehdi Nikkhah, Mark Allen

Keywords(s): Bio-Technology, Materials and Electronics

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Devices

Tumor Microenvironments/Models on a Microfluidic Chip

The tumor microenvironment is a complex milieu consisting of numerous cell types, packed in an extracellular matrix, along with a dense network of capillaries. Research has shown that crosstalk between cancer cells and the microenvironment has great influence on the potential for metastasis and disease progression, however the lack of physiologically...

Published: 2/23/2023 | Inventor(s): Mehdi Nikkhah, Roger Kamm, Danh Truong

Keywords(s): Bio-Technology, Medical Devices and Imaging

Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Biomaterials, Diagnostic Assays/Devices, Life Science (All LS Techs)

Injectable Microengineered Tissues for Cardiac Regeneration

Each year, millions of patients, globally, suffer from heart failure and cardiovascular disease. Stem cell transplantation and tissue engineering strategies have tremendous potential for repair and/or regeneration of injured myocardium. The major hurdles in stem cell transplantation are poor cell survival, insufficient cardiogenic differentiation,...

Published: 2/23/2023 | Inventor(s): Mehdi Nikkhah, Brent Vernon

Keywords(s): Biological Cell Manipulation, Cell Culture, MEMS, Tissue, Tissue Repair

Category(s): Life Science (All LS Techs), Biomaterials, Advanced Materials/Nanotechnology, Non-Cancer Therapeutics