Search Results - biomaterials

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A novel Scaffold for Mode-Selective Inhibition of TRPV1

Pain is estimated to affect about 30% of the world’s population and treatment is challenging because of issues with addiction and withdrawal which accompany many current analgesics. Human TRPV1 is a widely expressed nociceptor and is a desirable target to modulate diverse human pathophysiologies, including pain, obesity, and diabetes, among others....

Published: 4/2/2025 | Inventor(s): Wade Van Horn, Pankaj J. Pasricha

Keywords(s):

Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Advanced Materials/Nanotechnology, Artificial Intelligence/Machine Learning, Biomaterials

Biomaterial for Preventing Postoperative Intestinal Adhesions

Intra-abdominal adhesions, also known as postoperative peritoneal adhesions (PPA) remain a challenging issue in the US healthcare system. It is estimated that over 90% of gastrointestinal (GI) surgical procedures result in PPA formation, regardless of the location or surgical technique used. PPAs can also develop in response to tissue damage caused...

Published: 2/20/2025 | Inventor(s): Kaushal Rege, Vanshika Singh, Muhammad Raisul Abedin, Jordan Yaron

Keywords(s):

Category(s): Biomaterials, Life Science (All LS Techs), Manufacturing/Construction/Mechanical, Medical Devices

Metabolic Reprogramming of Immune for Autoimmune Disorders Prevention/Reversal

Antigen-specific immune suppression or tolerance is a highly attractive strategy to prevent inflammation-induced tissue damage in rheumatoid arthritis (RA). Although there is insufficient knowledge about autoantigens in human RA, generating and expanding synovium-specific regulatory T cells, and suppressing synovium-specific follicular T-helper cells,...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Joslyn Mangal

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals

Neutrophil based CAR Therapies for Treatment

Chimeric antigen receptor (CAR)-T-cell-based immunotherapies have dramatically improved survival in cancer patients. Unfortunately, CAR-T cell therapies are associated with severe neurotoxicity, adverse events during clinical trials, and cytokine storm syndrome among others. Therefore, there is a great need to develop strategies that can keep the benefits...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Mamta Wankhede

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies

Metabolite Delivery for Modulating Metabolic Pathways of Cells

There is a great need to deliver metabolites intracellularly without modifying the metabolite itself and rescue immune cells against metabolic exhaustion. In cancer therapy, metabolic pathway inhibitors are used that starve both cancerous cells as well as non-cancerous cells. Therefore, the ability to target specific immune cells and deliver metabolites...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer Therapeutics, Cancer, Life Science (All LS Techs), Pharmaceuticals, Nucleic Acid/Peptide/Protein Therapies

Central Carbon Metabolite Based Polymers for Immunotherapy

Inhibition of glycolysis or glutaminase pathway is an effective strategy to prevent cancer cell growth in vitro and in vivo. However, these pathways are also utilized by immune cells to mount responses against cancer cells, and therefore, utilizing, immunotherapies in the presence of such inhibitors is challenging. Thus, there is a need for technologies...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Sahil H Inamdar

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals

Central Carbon Metabolite Based Polymers for Tissue Regeneration

There is a rich history of successful drug delivery carriers made of biodegradable biomaterials. Biomaterials may degrade into metabolic by-products, which are capable of modulating the function of immune cells, including alpha-ketoglutarate (aKG), which induces alternative activation (immunosuppressive phenotype) in macrophages through metabolic reprogramming....

Published: 2/19/2025 | Inventor(s): Abhinav Acharya, Kaushal Rege

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Non-Cancer Therapeutics, Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Cancer

Rescue from Glycolysis and mRNA Based Vaccines

Glycolysis inhibition in cancer cells has long been recognized as a viable strategy to prevent cancer cell growth. Cancer cells are known to have a high glucose consumption rate as a metabolism adaptation mechanism called the Warburg effect. Activated immune cells also rely on glycolysis for their energy needs. For example, glycolysis is essential for...

Published: 2/19/2025 | Inventor(s): Abhinav Acharya

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Life Science (All LS Techs), Nucleic Acid/Peptide/Protein Therapies, Pharmaceuticals, Vaccines/Antimicrobials, Cancer, Cancer Therapeutics, Biomaterials

Metabolically-fit Immunotherapies Portfolio

M23-139L – Inducing or Rescuing Glycolysis in Cancer Cells. Compositions that selectively block glycolysis in cancer cells while simultaneously enable glycolysis in non-cancer cells, such as macrophages, T cells, NK cells, etc. Vaccine formulations have been developed and tested on mice with positive results. Please see the published PCT (WO2024151709A1)...

Published: 2/13/2025 | Inventor(s):

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Biological Nanotechnology, Cancer, Cancer Therapeutics, Life Science (All LS Techs), Non-Cancer Therapeutics, Pharmaceuticals, Vaccines/Antimicrobials

Antibacterial Coagulating Gel Spray

Blood loss and infections are a major cause of concern and death for traumatic injuries and wounds. It is estimated that blood loss accounts for more than 35% of all prehospital deaths in trauma patients. Thus, it is imperative that bleeding is stopped quickly and at the point of care. While there are many products to staunch bleeding, including gauze...

Published: 3/11/2025 | Inventor(s): Emily Byrne, Grace Billingsley, Tran Nguyen, Alfonso Gomez-De Leon, Oscar Voeller, Sarah Stabenfeldt, Jessica Weaver

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Devices

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