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Silver Oxide Ionic Conductors For High-Performing Alkaline Fuel Cells
Silver oxide nanoparticles are used as hydroxide ionic conductors for high-performing, durable, and low-cost anion exchange membrane fuel cells (AEMFCs) and anion exchange membrane water electrolyzers (AMWEs). Problem: Hydrogen energy technologies provide a low-cost source of clean energy derived from chemical reactions between hydrogen and oxygen....
Published: 2/16/2026   |   Inventor(s): Thomas Mallouk, Wonil Jung, Jeehoon Shin
Keywords(s): Autonomous Vehicles
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Energy
A Method for One-Step, Aqueous Phase Generation of Ultrasmall Inorganic Nanoparticles for Biomedical Applications.
A method to generate homogenous and stable inorganic nanoparticles (NPs) using a microfluidic device with two jet inlets. Problem: Inorganic nanoparticles have promise as contrast agents and therapeutics due to their high renal clearance and therefore low toxicity. However, they are limited by factors including complex synthesis routes with unfavorable...
Published: 1/21/2026   |   Inventor(s): David Cormode, Hyun (Michel) Koo, Nil Kanatha Pandey, Andrea Kian, Portia Maidment, Derick Rosario Berrios
Keywords(s): Microfluidics, Platform Technology, Radiology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
A Potent HIV Treatment with Low Toxicity
A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells. Problem: 37 million people worldwide currently live with HIV and an estimated 2-3 million new infections occur annually. While antiretroviral therapies do exist for those with the disease, therapy interruption leads to the re-emergence of...
Published: 11/11/2025   |   Inventor(s): Amos Smith, Xuchen Zhao, Tyler Higgins, Andres Finzi, Shilei Ding, Daniel Lee, Marzena Pazgier, Dung Nguyen, William Tolbert
Keywords(s): Drug Target, HIV/AIDS, Small Molecule, Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies. Problem: Chimeric antigen receptor (CAR)-T cell therapy has transformed cancer treatment by engineering patients' T cells to precisely target and eradicate cancer cells....
Published: 8/28/2025   |   Inventor(s): Jina Ko, Jianhua Lim
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Peptides For Solid Cancer Tumor Immunotherapy Treatment
Short, multivalent peptide antagonists to block macrophage immune-receptor SIRPα, promoting cancer cell phagocytosis. Problem: Modern cancer cell immunotherapies incorporate immune checkpoint blockade mechanisms, where prominent therapies target functionally suppressed immune cells in tumor microenvironments. Relieving this suppression allows...
Published: 9/17/2025   |   Inventor(s): Dennis Discher, AbdelAziz Jalil
Keywords(s): Cell Therapy, Immunology, Oncology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 8/19/2025   |   Inventor(s): Yue Huang, Hyun (Michel) Koo, David Cormode
Keywords(s): Bioengineering, Dentistry, Infectious Disease, Microbiome, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 8/1/2025   |   Inventor(s): Huafeng Wei, Qing Cheng Meng, Ge Liang, Maryellen Eckenhoff
Keywords(s): Aging, COVID-19, Nanotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Animal Health, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Food Science and Nutrition, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Quick, Scalable, and Precise Method to Produce Uniform Superparticles for Optical and Magnetic Applications
A method to cluster nanocrystals into uniform superparticles using a source-sink emulsion system. Problem: Superparticles present a compelling platform for customizable microscale magnets, sensors, and lasers. However, current manufacturing processes are slow, expensive, and imprecise resulting in loosely packed and polydisperse superparticles. Existing...
Published: 1/18/2026   |   Inventor(s): Emanuele Marino, Sjoerd van Dongen, Thomas Kodger, Christopher Murray
Keywords(s): Electronic Materials, Nanotechnology, Optics & Photonics , Quantum Dots and Related Fabrication
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Method to Alleviate Side Effects of CAR T Cell Immunotherapies
CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity). Problem: CAR-T cell therapies lead to many adverse side effects such as cytokine release syndrome (CRS) and neurotoxicity. It has been shown that 20-70% of patients receiving...
Published: 12/8/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong
Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunoncology, Immunotherapy, Oncology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
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