Search Results - marcello+giulianotti

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Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory
Alternative Gαs-promoting agonist Bronchodilator
­Competitive Advantages Novel compounds and methods for selecting targeting β2AR receptors to treat obstructive lung diseases The method might improve airway response with reduced tachyphylaxis Biasing towards β-arrestin and away from G protein coupling can be attained, which can be therapeutically favorable for certain receptors...
Published: 5/23/2024   |   Inventor(s): Stephen Liggett, Donghwa Kim, Marcello Giulianotti
Keywords(s): Biotechnology, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
BIS-Cyclic Guanidine Compounds as Novel Anti-Bacterial Agents
Competitive Advantages Low toxicity to human cells Potent anti-biofilm properties Effective against ESKAPE pathogens Summary By employing synthetic combinatorial libraries, our inventors have synthesized a class of bis-cyclic guanidine compounds that were found to have anti-bacterial activity against all six ESKAPE human pathogens....
Published: 8/26/2023   |   Inventor(s): Marcello Giulianotti, Radleigh Santos, Renee Fleeman, Richard Houghten, Adel Nefzi, Lindsey Shaw
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources