Search Results - bill+baker

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New natural product scaffolds with activity against respiratory syncytial virus from the Antarctic Sponge Suberites sp.
­Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...
Published: 3/20/2024   |   Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock
Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases
Methods for the Treatment of Inflammation
­Advantages: Exceptional precision in addressing inflammation, minimizing potential side effects. Unique COX-2 interaction reduces the risk of adverse reactions. Versatile effectiveness across various inflammatory disorders, providing relief to a wide range of patients. Summary: This technology addresses a significant healthcare challenge...
Published: 9/3/2024   |   Inventor(s): Bill Baker, Sofia Kokkaliari, James Leahy, Wayne Williams
Keywords(s): Inflammation, Pain Relief / Management
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Oncology
Antimalarial peptides
­Competitive Advantages Potential treatment for malaria Could be effective against drug resistant strain Dd2 The resulting compounds showed no significant cytotoxicity Summary Malaria, caused by the parasite Plasmodium falciparum, continues to threaten much of the world population and there is a pressing need for expanding treatment options....
Published: 9/3/2024   |   Inventor(s): Bill Baker, Joe Bracegirdle, James Rocca, John Adams, Nerida Wilson, Debora Casandra, Xingmin Sun, Anne-Claire Limon
Keywords(s): Infectious Diseases Treatment, Peptides, Therapeutics
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Infectious Diseases
Leishmania Inhibitors Derived from Deep-Sea Coral
Competitive Advantages Specific inhibition of Leishmania donovani parasites A natural drug candidate Does not produce toxic side effects Summary Our researchers have identified a novel metabolite derived from an Antarctic marine coral that shows promise as a new treatment option for leishmaniasis infections. Antactic marine invertebrates are...
Published: 6/26/2024   |   Inventor(s): Bill Baker, Nerida Wilson, Dennis Kyle, Anne-Claire Limon
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical
Antibiofilm terpenoids derived from the Antarctic sponge Dendrilla membranosa
Competitive Advantages New natural products and derivatives that are effective at eradicating Methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii biofilms Not cytotoxic to mammalian cells Summary Biofilms are formed by all bacterial species. In the context of human disease, biofilms are the driving force behind many...
Published: 9/3/2024   |   Inventor(s): Bill Baker, Lindsey Shaw, Andrew Shilling, Alexandre Bory, Jessie Adams, Charles Amsler, James McClintock
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical
Chromatographic Editing of Complex Mixtures
Competitive Advantages Modifies complex extracts from plants Prepare pharmaceutical compositions Applicable to other complex mixtures Summary Our researchers have developed a method of modifying complex extracts in which components or mixtures of components are selectively removed or added, thus providing a complex mixture that does not naturally...
Published: 6/8/2023   |   Inventor(s): Bill Baker
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
MRSA Biofilm Inhibition
Competitive Advantages A novel antibiofilm agent Treats and prevents biofilm growth Inhibits drug resistant bacterial infections including MRSA Low toxicity towards mammalian cells Summary USF researchers have developed a method of treating or preventing drug resistant bacterial infections including methicillin-resistant biofilm infections...
Published: 7/19/2023   |   Inventor(s): Bill Baker, Lindsey Shaw, James McClintock, Charles Amsler, Jacqueline Fries, Christopher Witowski, Renee Fleeman
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Antimicrobials From an Epigenetics Based Fungal Metabolite Screening Program
USF researchers have identified five novel antimicrobial compounds applicable against several drug targets such as ESKAPE pathogens, Leishmania donovani, Mycobacterium tuberculosis (TB), Clostridium difficile, Naegleria fowleri, and cancer. These five compounds were isolated via a fungal metabolite screening program. Each compound exhibited specific bioactivity...
Published: 8/25/2023   |   Inventor(s): Bill Baker, Danielle Demers
Keywords(s): Medical Pharmaceuticals, Pharmaceuticals
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Treatment for the Neglected Tropical Disease Leishmaniasis
Competitive Advantages Potent activity against Leishmaniasis parasite Low toxicity to healthy cells Parasite shows no resistance Summary The marine sponge, Dendrilla membranosa, produces a series of compounds with varying degrees of biological activity against the parasite Leishmania donovani. USF researchers have developed novel...
Published: 8/26/2023   |   Inventor(s): Brian Vesely, Christopher Witowski, Dennis Kyle, John Maschek, Bill Baker
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Myricanol Derivatives and Uses Thereof for the Treatment of Neurodegenerative Diseases
Competitive Advantages Causes significant reductions in tau accumulation May treat a variety of tauopathies A natural treatment option Compounds exhibit low toxicity and don’t alter GADPH levels Summary USF researchers have found that myricanol derivatives may be an effective treatment option for many neurodegenerative...
Published: 8/27/2023   |   Inventor(s): Bill Baker, Laurent Calcul, Umesh Jinwal, Chad Dickey(VA) (DECEASED - See Notes)
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
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