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Search Results - genetics
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Targeting Cellular Senescence by PD-L1 Binding Peptide Engineered Extracellular Vesicles
Advantages: Engineered extracellular vesicles (EVs) by surface modification with PD-L1 binding peptide and PEGylation to target senescent VSMCs. Promising novel interventions for age-related and vascular diseases. Efficacy: Proven uptake of modified EVs in the aorta of old mice and senescent VSMCs. Summary: Targeting senescent cells, particularly...
Published: 8/22/2024
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Inventor(s):
Wanling Xuan
,
Srinivas Tipparaju
,
Vijaykumar Sutariya
Keywords(s):
Drug Delivery and Nanomedicine
,
Genetics
,
Peptides
Category(s):
Technology Classifications > Medical > Medical Nanotechnology
,
Technology Classifications > Medical > Biotechnology
Soy Isoflavones For Asthma Prevention
Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....
Published: 1/4/2024
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Inventor(s):
Seong Cho
,
Raj Kumar
Keywords(s):
Genetics
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Electronics > Food Sciences
Novel FOXO1 Inhibitor for the Restoration of Lymphatic Valve Growth in Congenital Lymphedema
Advantages: Foxo1 inhibitor increased the expression levels of valve-forming genes in vitro and valves in vivo MOA: Foxo1 inhibition increases β-catenin and activates downstream genes FOXO1 inhibition can be a viable strategy to rescue valve defects in congenital lymphedema Summary: Mutations in many genes that regulate lymphatic...
Published: 9/3/2024
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Inventor(s):
Ying Yang
Keywords(s):
Genetics
,
Immunology
,
Medical Therapeutics Gene Therapy
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
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Technology Classifications > Medical > Biotechnology
Method for measuring Alu RNA
Advantages: Accurate Quantification: The competitive RT-PCR method allows for precise measurement of the ratio between fl-Alu and sc-Alu transcripts. Sensitivity: The assay can detect even low levels of Alu RNA expression. Versatility: The primer set used in the assay can amplify the most abundant form of Alu, making it applicable for various samples...
Published: 5/20/2024
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Inventor(s):
Hana Totary-Jain
Keywords(s):
Autoimmune Diseases
,
Cancer
,
Genetics
,
Infectious Diseases
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Cancer
Method to visualize Alu RNA in tissue
Advantages: Spatial localization Compatibility with Fixed Tissues Multiplexing Capabilities Business Summary: Retrotransposons (RTs) are the most abundant class of the transposable elements that comprise approximately 45% of the human genomic sequence, of which Alu repeats (Alus) are the most abundant and comprise 11% of the genomic sequence....
Published: 5/20/2024
|
Inventor(s):
Hana Totary-Jain
Keywords(s):
Genetics
,
Medical Devices
,
Research Tools
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
Countering Fragile X Syndrome with Reelin
Advantages: Precision Targeting Minimized Side Effects Durability Business Summary: Reelin in Fragile X Syndrome presents a novel and innovative strategy for addressing Fragile X Syndrome (FXS), a common inherited intellectual disability. This study is distinguished by its meticulous analysis of the distinctions between pre- and post-synaptic...
Published: 8/22/2024
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Inventor(s):
Nicole Morrill
,
Kevin Nash
Keywords(s):
Biotechnology
,
Genetics
,
Health Tech
,
Medical Diagnostics
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Medical Diagnostics
Improved Method for the Assessment of DNA Damage (The Comet Assay)
Competitive Advantages Increase in number of cell-containing slides being processed at a time. Slide carriers facilitate parallel, batch processing of multiple slides reducing manual handling and decreases the risk of damage/loss of fragile cell-containing gels. The slide carriers make for easy insertion and removal of slides from the electrophoresis...
Published: 7/17/2023
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Inventor(s):
Marcus Cooke
,
Mahsa Karbaschii
Keywords(s):
Biotechnology
,
Genetics
,
Health Tech
,
Medical Devices
Category(s):
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Biomaterials
Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia. Changes in neuronal Ca2+ concentration...
Published: 3/4/2024
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Inventor(s):
Venkat Venkataraman
,
Anuradha Krishnan
,
Jeffrey Viviano
,
Jingyi Zhang
Keywords(s):
Alzheimer's
,
Calcium
,
Genetics
,
Neurology
,
Neuromuscular
Category(s):
Human Health Care > Therapeutics
Neuronal calcium sensor proteins as potential therapeutic targets in circadian rhythm and sleep disorders
Sleep health and sleep disorders are major problems. In the US, an estimated 1/3rd of adults and 2/3rds of highschool aged young adults do not get the recommended amount of sleep. Lack of sleep and poor sleep hygiene is associated with a number of health problems. These include obesity, depression, and cardiovascular disease. Additionally, specific...
Published: 3/5/2024
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Inventor(s):
Venkat Venkataraman
Keywords(s):
Circadium
,
Genetics
,
Sleep
,
Therapeutic
Category(s):
Human Health Care > Therapeutics