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Targeting mDia formins to halt tumor microtube formation, invasion, and proliferation in brain tumors
Project ID D2019-34 Background Tumor therapies must overcome complex obstacles, such as cellular invasion, chemoresistance, and radioresistance. Cells within a brain tumor often form specialized ultralong cellular projections called tumor microtube (TM) projections that allow them to invade new areas of the brain. The networks formed by TMs interconnect...
Published: 6/18/2024   |   Inventor(s): Kathryn Eisenmann, Krista Pettee, Kathryn Becker
Keywords(s): Tumor microtubes, Cancer, Formin, Glioblastoma, High-grade glioma, Invasion, mDia
Category(s): Oncology, Neuroscience