Search Results - invasion

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Antisense Oligonucleotides against Cancer Cell Migration and Invasion
Abstract: Advanced stage cancers are typically marked by metastases of the primary cancer to secondary sites such as lungs, liver, and bones. Such metastatic cancers result in strikingly low 5-year survival rates, underscoring the need for novel therapeutics. For example, bone metastasis of primary breast cancer has a 5-year survival rate of 13%, lung...
Published: 4/8/2024   |   Inventor(s): Stavroula Mili
Keywords(s): Antisense, APC, CANCER, Invasion, Metastasis, MIGRATION, Mili, Net1, OLIGO, oligonucleotide, Oncology, Rab13, RNA
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Targeting mDia formins to halt tumor microtube formation, invasion, and proliferation in brain tumors
Project ID D2019-34 Background Tumor therapies must overcome complex obstacles, such as cellular invasion, chemoresistance, and radioresistance. Cells within a brain tumor often form specialized ultralong cellular projections called tumor microtube (TM) projections that allow them to invade new areas of the brain. The networks formed by TMs interconnect...
Published: 6/18/2024   |   Inventor(s): Kathryn Eisenmann, Krista Pettee, Kathryn Becker
Keywords(s): Tumor microtubes, Cancer, Formin, Glioblastoma, High-grade glioma, Invasion, mDia
Category(s): Oncology, Neuroscience