Search Results - vegf

2 Results Sort By:
Engineered T Cells Capable of Simultaneous Tumor Targeting and Alteration of Tumor Microenvironment Through Vasculature Normalization (UCLA Case No. 2023-264)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have built a series of chimeric antigen receptor (CAR)-T cells that target different antigens and secrete different anti-angiogenic proteins. Additionally, researchers also constructed bispecific CARs that respond to tumor antigen and pro-angiogenic molecules. BACKGROUND:...
Published: 6/27/2024   |   Inventor(s): Yvonne Chen
Keywords(s): Cancer, Cancer Immunotherapy, CAR-T cell therapy, immunosuppression, Immunosuppressive Drug, Immunotherapy, solid tumors, Tumor microenvironment, tumor vasculature, VEGF
Category(s): Therapeutics > Oncology
Thermoresponsive Injectable Microparticles-Gel Composites with Low Dose of Recombinant BMP-9 and VEGF for Bone Repair
Project ID: D2019-30 Background: With an estimated 6.3 million bone related injuries in the US, the cost for treating has skyrocketed. While autograft methods are associated with morbidity and pain along with high resorption rate, allograft methods are prone to a high risk of disease transmission and immunogenic rejection. Thus, there is an increasing...
Published: 5/9/2024   |   Inventor(s): Ambalangodage Champa Jayasuriya, Bipin Gaihre
Keywords(s): Allograft, Autograft, Biomaterials, BMP-9, Bone Regeneration, Bone Repair, Microparticle Gel, Orthopedic, VEGF
Category(s): Long Bone/Joint Repair, Spine, Medical Device