Search Results - richard+siegel

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Antibodies Against TL1A, a TNF-Family Cytokine, for the Treatment and Diagnosis of Autoimmune Inflammatory Diseases
Autoimmune inflammatory diseases occur in greater than five percent of the United States population; this disease group includes asthma, multiple sclerosis, rheumatoid arthritis, and lupus. Treatments generally include immunosuppressants or anti-inflammatory drugs, which can have serious side effects; recently, more specific immunomodulatory therapies...
Published: 12/27/2024   |   Inventor(s): Francoise Meylan, Yun-Jeong Song, Richard Siegel
Keywords(s): antibodies, ANTIBODY, ANTI-HUMAN, Anti-mouse, Autoimmune, diagnostic, DR3, IA3XXX, IAXXXX, IB3XXX, IBXXXX, Immunomodulation, immuno-modulator, immunomodulatory, INFLAMMATORY, inflammatory disease, IXXXXX, monoclonal, Monoclonal Antibodies, Monoclonal Antibody, Patent Category - Biotechnology, therapeutic, TL1A, tnf, TNFRSF25, TNFSF15, tumor necrosis factor, USES
Category(s): Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Immunology
Amelioration of Inflammatory Arthritis Targeting the Pre-ligand Assembly Domain (PLAD) of Tumor Necrosis Factor Receptors
The invention relates to compositions of matter and methods for treating arthritis by modulating Tumor Necrosis Factor Alpha (TNF-alpha) signaling. TNF-alpha plays a key role in the pathogenesis of numerous diseases including rheumatoid and septic arthritis, and other autoimmune and inflammatory diseases. TNF-alpha mediates its effects through receptors...
Published: 10/28/2024   |   Inventor(s): Michael Lenardo, Francis Chan, Richard Siegel
Keywords(s): ASSEMBLY, BCXXXX, CB3AXX, CBXXXX, CC1XXX, CCXXXX, CXXXXX, Domain, factor, FAMILY, FUNCTION., Identification, Listed LPM Hastings as of 4/15/2015, Mediates, NECROSIS, Novel, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRE-LIGAND, RECEPTOR, SACGHS DNA Patent Initial Set, That, tumor
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology
Silicone Based Nanocomposites Including Inorganic Nanoparticles and Their Methods of Manufacture and Use
Reference #: 00992 Background: Compared with pure silicone polymer, silicone-based nanocomposites can realize enhanced mechanical, thermal, electric, dielectric and optical properties by adding functional inorganic nanofillers. However, the incompatibility between inorganic nanofillers and an organic matrix normally leads to large agglomerates of the...
Published: 12/8/2017   |   Inventor(s): Brian Benicewicz, Anand Viswanath, Linda Schadler, Richard Siegel, Ying Li, Peng Tao
Keywords(s):  
Category(s): Nanotechnology, Chemistry and Biochemistry