Search Results - weizhao+chen

19 Results Sort By:
SECURE BIOMETRIC RECOGNITION USING EFFICIENT NEURAL NETWORKS
Value proposition Face Recognition (FR) has become integral to identity management in many practical applications, from unlocking personal devices to facilitating law enforcement and accessing financial services. These systems process sensitive biometric data that, if compromised, can lead to privacy invasions, identity theft, and unauthorized surveillance....
Published: 9/15/2025   |   Inventor(s): Vishnu Boddeti, Wei Ao
Keywords(s):  
Category(s): Computer Software, Informatics, Data Processing/Analysis
Reducing Ischemic Kidney Injury Through Synchronization Modulation Electric Field (SMEF)
Advantages SMEF enables ATP regeneration under ischemic conditions Non-invasive, broad-spectrum applicability to multiple cell and tissue types Enhances organ viability during transplantation Broad Applicability: mechanism is relevant to other ischemic injuries (e.g., heart, brain, liver), opening doors to multi-organ applications Summary Kidney...
Published: 8/8/2025   |   Inventor(s): Wei Chen, Ruisheng Liu
Keywords(s): Organ Transplantation, Renal / Kidney
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering
Non-Invasive, Early-Stage Liver Fibrosis Diagnostic
Description This technology is a cutting-edge non-invasive liver fibrosis detection technology, a revolutionary advancement in the early diagnosis of liver fibrosis. Detecting liver fibrosis early is crucial because it helps address and potentially prevent the progression of liver diseases that can lead to more severe conditions such as cirrhosis,...
Published: 3/12/2025   |   Inventor(s): Yi Jiang, Hao Chen, Sergey Klimov, Bin Zhang
Keywords(s): Liver Disease Detection
Category(s): Diagnostic, Imaging
Single domain CD4, HIV-1 Antibodies, and Fusion Proteins for treatment of HIV
Abstract: Soluble forms of human CD4 (sCD4) inhibit HIV-1 entry into immune cells.  Different forms of sCD4 and their fusion proteins have been extensively studied in animal models and clinical trials as promising HIV-1 inhibitors. However, they have not been successful in clinical trials due to their transient efficacy.  sCD4 is also known to interact...
Published: 4/22/2025   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen
Keywords(s): CD4, Dimitrov, fusion protein, HIV-1, Single Domain Antibodies (sdAb)
Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
HIV-1 Therapeutic Inhibits Viral Entry
Abstract: Soluble forms (sCD4) of human CD4, the HIV-1 primary receptor, are potent HIV-1 entry inhibitors. Both four-domain (D1-4) and two-domain (D1D2) sCD4 and their fusion proteins have been tested as candidate therapeutics in animal models and in human clinical trials and were well tolerated by patients with no significant clinical or immunologic...
Published: 4/22/2025   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Prabakaran Ponraj
Keywords(s): CD4, entry inhibitor, HIV, MHCII, soluble expression
Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Antibodies and CARs Targeting FLT3 for the Treatment of Acute Myeloid Leukemia and Acute Lymphoid Leukemia
Abstract: Fms-like tyrosine kinase 3 (FLT3) is a cytokine receptor which belongs in the receptor tyrosine kinase class III.  FLT3 is expressed on the surface of many hematopoietic progenitor cells and plays an important role in hematopoietic stem/progenitor cell survival and proliferation.  It is often overexpressed in acute lymphoblastic leukemia (ALL)...
Published: 4/22/2025   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Terry Fry, Christopher Chien, Haiying Qin
Keywords(s): acute lymphocytic leukemia, acute myeloid leukemia, ALL, AML, CANCER, cancer therapeutic, chimeric antigen receptor (CAR), Flt3, Monoclonal Antibody
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
Fusion Proteins as HIV-1 Entry Inhibitors
Abstract: Soluble forms of human CD4 (sCD4) inhibit HIV-1 entry into immune cells.  Different forms of sCD4 and their fusion proteins have been extensively studied as promising HIV-1 inhibitors – including in animal models and clinical trials.  However, they have not been successful in human studies due to their transient efficacy.  sCD4 is also known...
Published: 4/22/2025   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Tianlei Ying
Keywords(s): antibody dependent cellular cytotoxicity (ADCC), Class II major histocompatibility complex (MHCII), Dimitrov, fusion protein, HIV-1, sCD4
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Identification and Use of Heterocyclic Alcohol Compounds for the Treatment of SULT1A1-expressing Cancers
This technology includes the identification and use of heterocyclic alcohol compounds, including RITA and N-BIC, for the treatment of SULT1A1-expression cancers. A high-throughput screen (qHTS) was performed using >1,000 caner cell lines identified a compound called YC-1 (also called Lificiguat) that is effective across cancer cell types that express...
Published: 10/28/2024   |   Inventor(s): Min Shen, Ke Kong, Toble Lee, Samarjit Patnaik, Olivia Lee, Jonathan Shrimp, Mindy Davis, Juan Marugan, Wei Zhao, Matthew Hall
Keywords(s): Agents, Alcohol, anti-cancer, Class, compounds, HETEROCYCLIC, SULT1A1-dependent, VCXXXX, WKXXXX, XCXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Application of the Synchronization Modulation Technique of the Na/k Pumps in Treatment of Muscle Fatigue
­Competitive Advantages Postpones or relieves muscle fatigue Could reduce recovery time in different diseases Reduces ATP consumption thus increases energy for muscle contraction Summary Muscle fatigue is an important public health problem for large population especially for the people with occupations of athlete, soldier, and heavy-duty...
Published: 7/11/2023   |   Inventor(s): Wei Chen, Jason Mast, Pengfei Liang
Keywords(s): Pain Relief / Management, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry
1 2