Search Results - haiying+qin

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Bivalent, Dual Specific Anti-CD22 Anti-CD19 Chimeric Antigen Receptors (CARs)
Abstract: Chimeric antigen receptors (CARs) combine an antibody-based binding domain (and single chain fragment variable region, scFv) with T cell receptor signaling domains (CD3 zeta with a costimulatory domain, typically CD28 or 41BB). When T cells express CARs, they are activated in a major histocompatibility complex- (MHC) independent manner to...
Published: 4/8/2024   |   Inventor(s): Terry Fry, Crystal Mackall, Rimas Orentas, Haiying Qin, Waleed Haso
Keywords(s): Acute Lymphoblastic Leukemia, ALL, BISPECIFIC, Bivalent, CAR, CD19, CD22, Diffuse Large B-Cell Lymphoma, DLBCL, Dual-Specific Chimeric Antigen Receptors, Fry, Oncology, Pediatric Leukemia, Pediatric Lymphoma
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Antibodies and CARs Targeting FLT3 for the Treatment of Acute Myeloid Leukemia and Acute Lymphoid Leukemia
Abstract: Fms-like tyrosine kinase 3 (FLT3) is a cytokine receptor which belongs in the receptor tyrosine kinase class III.  FLT3 is expressed on the surface of many hematopoietic progenitor cells and plays an important role in hematopoietic stem/progenitor cell survival and proliferation.  It is often overexpressed in acute lymphoblastic leukemia (ALL)...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Terry Fry, Christopher Chien, Haiying Qin
Keywords(s): acute lymphocytic leukemia, acute myeloid leukemia, ALL, AML, CANCER, cancer therapeutic, chimeric antigen receptor (CAR), Flt3, Monoclonal Antibody
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
Genetically Modified Hematopoietic Stem And Progenitor Cells (HSPCs) And Mesenchymal Cells As A Platform To Reduce Or Prevent Metastasis, Treat Autoimmune And Inflammatory Disorders, And Rebalance The Immune Milieu And Dysregulated Niches
Abstract: Cancer cells can spread to various regions in the body in a process called metastasis which is associated with non-responsive to treatment and thus reduced survival. Identifying the markers of metastasis has been a major concern in the field of cancer diagnosis and therapy. Interestingly, research has shown that there is an increase in myeloid...
Published: 4/8/2024   |   Inventor(s): Rosandra Kaplan, Sabina Kratzmeier, Daneil Beury, Haiying Qin
Keywords(s): adoptive cell therapy, AUTOIMMUNE DISEASE, Cancer Immunotherapy, GEMys, Genetically Engineered Myeloid Cells, Kaplan, Metastasis, Platform Technology
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Dual Specific Anti-CD22 Anti-CD19 Bicistronic Chimeric Antigen Receptors (CARs)
Abstract: Treatment of B-cell acute lymphoblastic leukemia (ALL) and lymphoma using chimeric antigen receptors (CARs) targeting B-cell surface protein CD19 has demonstrated impressive clinical results in children and young adults. Despite the promising results from CD19 CAR therapy, up to 40% of patients, who initially achieve remission, eventually...
Published: 8/14/2024   |   Inventor(s): Haiying Qin, Terry Fry, Crystal Mackall
Keywords(s): Acute Lymphoblastic Leukemia, ALL, BICISTRONIC, CAR, CD19, CD22, Diffuse Large B-Cell Lymphoma, DLBCL, Dual-Specific Chimeric Antigen Receptors, Fry, Oncology, Pediatric Leukemia, Pediatric Lymphoma
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration
Multi-Resolution Foveated Laparoscope
Researchers at the University of Arizona have developed an optical design for laparoscopes that can obtain wide angle and high magnification images of a surgical area in real time. The two images enable seamless registration between the low and high-resolution images, providing surgeons with the best of both worlds. In addition, the innovation enables...
Published: 6/6/2024   |   Inventor(s): Hong Hua, Mike Nguyen, Yi Qin
Keywords(s): foveated imaging, laparoscope, multi-resolution
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics
Improved Illumination System of Laparoscope Using an Aspherical Lens Array
University of Arizona researchers have developed a more uniform illumination system for better medical images. The system directs outgoing rays from the fiber bundle to provide more uniform illumination, even with extended non-lambertian sources, allowing the full field of view to be fully observed with good detail. It is low cost and can be easily...
Published: 6/6/2024   |   Inventor(s): Hong Hua, Rengmao Wu, Yi Qin
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Lens & System Design, Technology Classifications > Imaging & Optics > Materials & Fabrication
Scalable Manufacturing of 2D Coordination Polymer Films
Background Two dimensional (2D) polymers are relatively new types of organic materials with remarkable electronic and structural properties, making them attractive for a variety of applications. Unlike traditional polymers, monomer building units are arranged in a sheet-like manner to form 2D networks of 2D polymeric materials. This opens a wide range...
Published: 2/23/2023   |   Inventor(s): Meng Wang, Yuxia Shen, Sefaattin Tongay, Matthew Green, Ying Qin, Sijie Yang
Keywords(s): Bio-Technology, Environmental, Materials and Electronics, Mechanical and Manufacturing
Category(s): Advanced Materials/Nanotechnology, Physical Science
2 Dimensional Coordination Polymers and Synthesis
Two-Dimensional Coordination Polymers for Enhanced Tunability of Two-Dimensional Materials Background Two-dimensional (2D) materials, such as graphene or MoS2, have recently attracted a great deal of attention due to their unique physical and chemical properties. In particular, 2D materials have been explored for applications in energy conversion,...
Published: 2/23/2023   |   Inventor(s): Matthew Green, Sefaattin Tongay, Meng Wang, Ying Qin
Keywords(s): Fuel Cells, Energy, Materials and Electronics
Category(s): Advanced Materials/Nanotechnology, Alternative Energy, Physical Science
HIGH OUTPUT, FLEXIBLE PIEZOELECTRIC DEVICES
Princeton Docket # 10-2585 Researchers at Princeton have developed a new design for highly flexible, high output piezoelectric assemblies. Princeton is seeking an industrial partner to commercialize this technology. Current and past devices have relied on low output piezoelectric compounds and mechanical...
Published: 6/27/2024   |   Inventor(s): Michael McAlpine, Yi Qi
Keywords(s):  
Category(s): Mechanical/Electrical Engineering