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Antibodies and CARs Targeting FLT3 for the Treatment of Acute Myeloid Leukemia and Acute Lymphoid Leukemia
Abstract: Fms-like tyrosine kinase 3 (FLT3) is a cytokine receptor which belongs in the receptor tyrosine kinase class III.  FLT3 is expressed on the surface of many hematopoietic progenitor cells and plays an important role in hematopoietic stem/progenitor cell survival and proliferation.  It is often overexpressed in acute lymphoblastic leukemia (ALL)...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Weizhao Chen, Terry Fry, Christopher Chien, Haiying Qin
Keywords(s): acute lymphocytic leukemia, acute myeloid leukemia, ALL, AML, CANCER, cancer therapeutic, chimeric antigen receptor (CAR), Flt3, Monoclonal Antibody
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
Compounds for Treating Cancer and Cancer Stem Cells
High-Throughput Assay and Compounds Selective for Targeting Refractory Cancers and Cancer Stem CellsCurrently, there are limited therapies available to treat people with refractory cancers like acute myeloid leukemia (AML), non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC). To solve this problem, University of Florida scientists...
Published: 11/15/2021   |   Inventor(s): Peter Sayeski, Amy Meacham, Christopher Cogle
Keywords(s): AML, Blood Vessels, Cancer, In vitro, leukemia, LLS, TPIMS
Category(s): Technology Classifications > Human Health Care > Therapeutics