Search Results - francoise+meylan

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Human TL 1A-transgenic Mouse as a Disease and Therapeutic Model
This technology includes mouse models of TL 1A diseases, such as inflammatory bowel disease and rheumatoid arthritis, to be used as a platform for studying therapeutic agents. The TNF family cytokine TL 1A co-stimulates T-cells through Its receptor and is required for autoimmune pathology driven by diverse T-cell subsets. Blocking TL 1A in mouse models...
Published: 7/30/2024   |   Inventor(s): Richard Siegel, Francoise Meylan
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Animal Models
Monoclonal Anti-mouse and Anti-human TL 1A Antibodies for Diagnostic and Therapeutic Utilization
This technology includes antibodies against TL 1A for the inhibition of TL 1A-DR3 interactions for the diagnosis and treatment of various autoimmune diseases. Through the use of our developed hamster anti-mouse and mouse anti-human monoclonal antibodies, we’ve demonstrated that treatment with anti-mouse TL 1A prevented collagen-induced arthritis...
Published: 7/30/2024   |   Inventor(s): Richard Siegel, Francoise Meylan, Yun-Jeong Song
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology
TL1A Transgenic Mice for the Study of Inflammatory Bowel Disease (IBD) and Allergic-Type Immune Responses
TL1A is a TNF family cytokine that co-stimulates T-cell proliferation and cytokine production through its interactions with the TNF family receptor DR3. TL1A-DR3 interactions have been shown to be important for the development of autoimmune inflammatory diseases, including inflammatory bowel disease (IBD). In order to probe the role of TL1A-DR3 interactions...
Published: 10/28/2024   |   Inventor(s): Francoise Meylan, Richard Siegel
Keywords(s): Allergic-type, Autoimmune, BOWEL, DR3, IBD, IDXXXX, IL-13, IMMUNE, INFLAMMATORY, inflammatory bowel disease, IXXXXX, Mouse, Murine, TL1A, TL1A/DR3, TLlA-transgenic, tnf, TNFSF15
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Antibodies Against TL1A, a TNF-Family Cytokine, for the Treatment and Diagnosis of Autoimmune Inflammatory Diseases
Autoimmune inflammatory diseases occur in greater than five percent of the United States population; this disease group includes asthma, multiple sclerosis, rheumatoid arthritis, and lupus. Treatments generally include immunosuppressants or anti-inflammatory drugs, which can have serious side effects; recently, more specific immunomodulatory therapies...
Published: 7/30/2024   |   Inventor(s): Francoise Meylan, Yun-Jeong Song, Richard Siegel
Keywords(s): antibodies, ANTIBODY, ANTI-HUMAN, Anti-mouse, Autoimmune, diagnostic, DR3, IA3XXX, IAXXXX, IB3XXX, IBXXXX, Immunomodulation, immuno-modulator, immunomodulatory, INFLAMMATORY, inflammatory disease, IXXXXX, monoclonal, Monoclonal Antibodies, Monoclonal Antibody, Patent Category - Biotechnology, therapeutic, TL1A, tnf, TNFRSF25, TNFSF15, tumor necrosis factor, USES
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Immunology