Search Results - bioluminescence

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Luminescent biosensor for detection of nucleotide sequences, small molecules, and proteins at the point-of-care
This technology is a modular, luminescent biosensor that rapidly detects DNA, RNA, small molecules, and proteins at the point of care, using a visible color change measurable by a smartphone, enabling fast, sensitive, and equipment-free diagnostics. Background: Molecular diagnostics is a rapidly evolving field that plays a critical role in the detection...
Published: 7/27/2026   |   Updated: 7/27/2026   |   Inventor(s): Harsimranjit Sekhon, Stewart Loh
Keywords(s): bio/chemical sensors, bioluminescence, biomarker diagnostics, biosensor, nanoluciferase, Technologies, therapeutic drug monitoring, Virus Detection
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics
Chromatic Bioluminescence as a Cellular Level Readout System of Neural Activity
This technique could be used to visualize neuronal activity in the brain, in nerves, or in ex vivo systems. Background: Some compounds can emit luminescence in response to changes in intracellular ion concentrations. Neuronal depolarization, and the generation of an action potential, involves an elevation in intracellular calcium, which causes the...
Published: 6/26/2026   |   Updated: 5/13/2025   |   Inventor(s): Stephen Macknik, Susana Martinez-Conde, Nozomi Nishimura, Christopher Schaffer
Keywords(s): bioluminescence, optogenetic brain system, prosthetic vision, restoration of vision, Technologies, visual cortex
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering
Lentiviral Vectors with Dual Fluorescence/Luminescence Reporters
Abstract: In research settings, visualization of tumors or tumor cells is often done using either bioluminescence or fluorescence. However, both of these methods have shortcomings: bioluminescence is not sensitive enough to sort individual tumor cells, and fluorescence cannot be used effectively to view internal tumors and is best used with surface...
Published: 7/17/2026   |   Updated: 8/2/2023   |   Inventor(s): Dominic Esposito, Chi-Ping Day, Glenn Merlino
Keywords(s): Bioluminescence, Fluorescence, tumor visualization, vectors
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
Bioluminescent Bladder Cancer Cell Line for Tracking Cancer Progression
Abstract: Bladder cancer is the fifth most common cancer in the United States and one of the costliest cancers to treat. Compared to other cancer types, bladder cancer has been understudied, and there is a need for informative mouse bladder cancer models that resemble the clinical situation and allow for evaluation of chemotherapeutic or immunotherapeutic...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Jeffrey Schlom, John Greiner
Keywords(s): Bioluminescence, Bladder cancer, LUCIFERASE, MB49, Schlom
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology