Search Results - t-cell

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Increased Therapeutic Effectiveness of PE-Based Immunotoxins
Abstract: Patients receiving immunotoxin cancer therapy are less likely to experience the deleterious side-effects associated with non-discriminate therapies such as chemotherapy or radiation therapy. Unfortunately, the continued administration of immunotoxins often leads to a reduced patient response due to the formation of neutralizing antibodies...
Published: 5/21/2024   |   Inventor(s): Ira Pastan, Masanori Onda, Wenhai Liu
Keywords(s): B-CELL, CHEMOTHERAPY, Human B cell epitopes, Immunogenic epitopes, Immunotoxin, Pseudomonas exotoxin A, T-cell
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Gene-based Diagnostic Predicts Patient Response to Cancer Immunotherapy
Abstract: Immunotherapy is a promising method of treating cancer that leverages the immune system to promote tumor rejection. However, certain somatic mutations in cancer cells confer resistance to T cell-mediated cytolysis. To improve the effectiveness of immunotherapies for cancer, there exists a need to prospectively identify patients who are most...
Published: 9/27/2024   |   Inventor(s): Shashankkumar Patel, Nicholas Restifo
Keywords(s): CRISPR, diagnostic, Gene, Immunotherapy, T-cell, tumor
Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
T-Cell Therapy Against Patient-Specific Cancer Mutations
Abstract: Human cancers contain genetic mutations that are unique to each patient. Some of the mutated peptides are immunogenic, can be recognized by T cells, and therefore, may serve as therapeutic targets. Scientists at the National Cancer Institute's Surgery Branch developed a method to identify T cells that specifically recognize immunogenic mutations...
Published: 4/8/2024   |   Inventor(s): Eric Tran, Yong-Chen Lu, Paul Robbins, Steven Rosenberg
Keywords(s): Cholangiocarcinoma, Immunogenic, Rosenberg, T-cell, Tran
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
T-Cell Therapy Against Patient-Specific Cancer Mutations
Abstract: Human cancers contain genetic mutations that are unique to each patient. Some of the mutated peptides are immunogenic, can be recognized by T cells, and therefore, may serve as therapeutic targets. Scientists at the National Cancer Institute's Surgery Branch developed a method to identify T cells that specifically recognize immunogenic mutations...
Published: 4/8/2024   |   Inventor(s): Eric Tran, Paul Robbins, Yong-Chen Lu, Steven Rosenberg
Keywords(s): Cholangiocarcinoma, Immunogenic, T cell, T-cell
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
T-Cell-Specific Gfi-1 Knockout Mouse
This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells....
Published: 10/28/2024   |   Inventor(s): William Paul (Estate Of), Jinfang (Jeff) Zhu
Keywords(s): BAXXXX, Cells, FUNCTION, Gfi-1, Gfi1[fl/fl]-CD4Cre, IMPORTANT, KO, Mouse, Regulatory, REVEALS, RXXXXX, Specific, Strain, T, T-cell
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, ResearchProducts > Animal Models