Search Results - eric+wang

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SPLICER: Small Molecule-Inducible Gene Expression Switches

Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...

Published: 9/2/2025 | Inventor(s): Eric Wang, Yu Zhou

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Autoregulated MBNL Gene Therapy for Myotonic Dystrophy

Next-Generation Gene Therapy Vectors with Tunable, Tissue-Specific, and Auto-Regulated Expression for Superior Safety and Efficacy This technology introduces recombinant adeno-associated virus (rAAV) vectors engineered to enable precise, regulated expression of therapeutic genes. Recombinant viruses can deliver therapeutic gene expression constructs...

Published: 9/2/2025 | Inventor(s): Eric Wang, Andy Berglund, Elizabeth Delgado, Jana Jenquin, Derek Muscato, Ona McConnell, Leanne Adams, Maria Valero Quiros

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Alternative Splicing Cassettes for AAV Gene Therapy Regulation

Uses Tissue-Specific Exons for Precise Control Therapeutic Cargo Delivery These alternative splicing cassettes use tissue specific exons to precisely deliver adeno-associated virus (AAV) cargo. AAVs are a commonly used gene therapy vector for delivering genetic material into cells. Current technology relies upon tissue specific promoters to guide and...

Published: 9/9/2025 | Inventor(s): Eric Wang, Keril Poukalov

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

CRISPR-associated Protein for Treating Neurological Diseases

Blocks Transcription of Expanded Microsatellite Repeats to Treat Muscle Degenerating DiseasesThis therapeutic precisely targets microsatellite repeats in the DNA sequence and blocks the transcription of a genetic mutation, called hexanucleotide repeat expansion, providing therapy for a variety of neurological and muscular degenerative diseases. The...

Published: 5/13/2025 | Inventor(s): Tanvi Saxena, Belinda Pinto, Eric Wang

Keywords(s): CRISPR, Neurological Diseases, Transcription

Category(s): Technology Classifications > Human Health Care > Therapeutics

Flumazenil for Treatment of CNS Symptoms in Myotonic Dystrophy

Application A class of drugs that inhibit molecules responsible for the severe nervous system complications associated with myotonic dystrophy. Key Benefits Potentially the first medication for treating the severe nervous system symptoms associated with myotonic dystrophy by targeting GABRG2. Transdermal and oral administration. May drive the...

Published: 2/28/2025 | Inventor(s): Gary Bassell, Andrew Jenkins, David Rye, Eric Wang, Maurice Swanson, Lyndon Lien

Keywords(s): Neurology and Pain Treatments

Category(s): TechPub Algolia > Therapeutics

Sigma-point filter-nased integrated navigation system

Summary This technique achieves for the navigational state of the system an estimation accuracy that is greater than that achievable with an extended Kalman filter-based probabilistic inference system. Technology Overview USA Today reports that the U.S. military, encouraged by the success of satellite-guided bombs and unmanned spy planes, plans to...

Published: 9/26/2023 | Inventor(s): Rudolph Van Der Merwe, Eric Wan, Simon Julier

Keywords(s): Software

Category(s): Software

Optimization of the Configuration of Pixilated Detectors for the X-Ray Spectroscopy of Hot Plasmas Based on the Shannon-Nyquist Theorem

Optimization of the Configuration of Pixilated Detectors Princeton Docket # 12-2829 Inventors from Princeton University's Plasma Physics Lab have developed a novel method of optimizing the configuration of pixilated radiation detectors, such that radiation in different x-ray energy ranges can be simultaneously recorded by a single detector. In order...

Published: 3/30/2022 | Inventor(s): Manfred Bitter, Kenneth Hill, Luis Delgado-Aparicio, Novimir Pablant, Eric Wang

Keywords(s): Imaging, Opto-Electronics/ELE ENG

Category(s): Mechanical/Electrical Engineering