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Bispecific Antibody Targeting Anthrax Toxins and Capsule for Enhanced Biodefense
The technology focuses on the development of a tetravalent bispecific antibody effective against Bacillus anthracis, the bacterium responsible for anthrax. This antibody combines the specificities of two monoclonal antibodies (mAbs): one targeting anthrax protective antigen (PA) and the other targeting the bacterial capsule. The anti-PA mAb shows potent...
Published: 12/10/2024   |   Inventor(s): Zhao Chun Chen, Robert Purcell, Mahtab Moayeri, Stephen Leppla
Keywords(s):  
Category(s): Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Advancements in Postexposure Prophylaxis: Evaluating High-Potency Rabies-Neutralizing Monoclonal Antibodies
This technology represents a significant advancement in the field of rabies prevention, focusing on the development of highly potent rabies-neutralizing monoclonal antibodies (mAbs) for use in postexposure prophylaxis (PEP). With two mAbs, F2 and G5a, displaying exceptional neutralizing titers of 1154 and 3462 International Units (IUs) per milligram,...
Published: 12/10/2024   |   Inventor(s): Zhaochun Chen, Robert Purcell, Joseph Blaney
Keywords(s):  
Category(s): Application > Diagnostics, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Antibodies, ResearchProducts > Research Equipment, TherapeuticArea > Infectious Disease
Placement of Spinal Cord Stimulation Leads
This technology focuses on improving spinal cord stimulation (SCS) treatments by helping physicians determine the optimal placement of stimulation leads on the body. The approach utilizes a specialized algorithm designed to predict the best lead locations for achieving effective pain relief and improved clinical outcomes. By integrating advanced imaging...
Published: 12/16/2024   |   Inventor(s): Julie Pilitsis, Ilknur Telkes, Nan-kuei Chen, Mitchell Bartlett
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Life Sciences, Technology Classifications > Medical Devices > Therapeutic, Technology Classifications > Software & Information Technology > Health IT
Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Device and Methods for Telehealth Wound Care
An inexpensive, hand-held optical device capable of imaging wounds for telehealth monitoring of healing and vascular structure. Background: Open sores and wound healing are a pressing concern in medical care of limited mobility patients. For instance, diabetic foot ulcers are associated with a 25% 5 year mortality rate as well as other complications....
Published: 12/4/2024   |   Inventor(s): Wenyao Xu, Jun Xia, Alexander Gherardi, Tianyu Chen
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Medical Devices, Technology Classifications > Medical Imaging
Origami-Inspired And Remotely Adjustable Pediatric Heart Implant
Pediatric pulmonary artery band (PAB) using origami-inspired fabrication that is remotely adjustable after implantation. Problem: Congenital heart defects affect 1% of births in the United States and can lead to irregular blood flow through the main pulmonary artery (MPA). A pulmonary artery band (PAB) is an implant that can be placed on the MPA to...
Published: 11/18/2024   |   Inventor(s): Cynthia Sung, Gabriel Unger, Mark Fogel, Jonathan Chen, Brianna Leung
Keywords(s): Bioengineering, Cardiovascular, Pulmonary, Soft Materials, Surgery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Robotics
NetSpec: An Automatic And Fast Network Specification Synthesis Toolkit
A specification-by-example toolkit that generates formal network specifications using only input-output examples. Problem: Many modern computer systems run on networks like cloud clusters or distributed systems. However, the network protocols that support the operation and security of these systems are notoriously difficult to debug. Formal network...
Published: 11/19/2024   |   Inventor(s): Boon Loo, Haoxian Chen, Mayur Naik, Chenyuan Wu, Mukund Raghothaman
Keywords(s): Software
Category(s): Technology Classifications > Computer Information Systems
Fluorescence lifetime imaging for retinal function assessment
This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...
Published: 10/24/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy
Fluorescence lifetime imaging for retinal function assessment
This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...
Published: 10/24/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy
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