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Search Results - ruisheng+liu
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Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 11/6/2024
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Inventor(s):
Jianfeng Cai
,
Heng Liu
Keywords(s):
Alzheimer's Disease
,
Biotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024
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Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Advanced Mobile Navigation and Mapping App
Improves mobile mapping and navigation apps by visualizing distant landmarks that typically fall outside the device display area. Background: Existing mobile map or navigation apps generally provide directions through distance and turn-by-turn instructions – for example, “after 1 mile, turn right on to Lakeview street.” Directions...
Published: 1/23/2024
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Inventor(s):
Rui Li
,
Jiayan Zhao
Keywords(s):
augmented reality
,
autonomous vehicle
,
spatial cognition
,
Technologies
,
visualization
,
wayfinding and navigation
Category(s):
Campus > University at Albany
,
Technology Classifications > Electronics
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Technology Classifications > Instrumentation
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Technology Classifications > Wireless Technologies
2022-116-1 Electrolyte Modulator Additive for Lithium-Ion Batteries
Summary: UCLA researchers in the Department of Chemical and Biomolecular Engineering have designed a MOF-based electrolyte modulator to mitigate the polarization of electrolytes in lithium-ion batteries for energy efficient electric vehicles. Background: To ensure a successful transition to electric vehicles, it is essential to develop low-cost...
Published: 7/19/2023
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Inventor(s):
Yunfeng Lu
,
Li Shen
,
Xinru Li
Keywords(s):
Charge Carrier
,
Electric Vehicle
,
Energy Density
,
Energy Efficiency
,
Hybrid Electric Vehicle
,
Lithium Battery
,
Lithium-Ion Battery
,
Metal-Organic Framework
,
Polarizer
,
Rechargeable Battery
,
Rechargeable Battery Thermal Conductivity
Category(s):
Electrical
,
Energy & Environment > Energy Storage
,
Energy & Environment > Energy Storage > Batteries
A Nanoparticle Delivery System for Treatment of Glomerular Diseases
Competitive Advantages Site-specific precise treatment for glomerular diseases High local therapeutic efficiency Minimized systemic side effects Summary Glomerulonephritis is a group of inflammatory diseases that damage the filters of the kidney, glomeruli. Glomerulonephritis requires aggressive immunosuppressive therapy, but unfortunately most...
Published: 1/22/2024
|
Inventor(s):
Ruisheng Liu
,
Samuel Wickline
,
Jin Wei
,
Hua Pan
,
Jie Zhang
Keywords(s):
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical > Pharmaceuticals
NKCC2flox Mice
Competitive Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing...
Published: 9/26/2023
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Inventor(s):
Ruisheng Liu
Keywords(s):
Diabetes
,
Laboratory Methods
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Research Tools/Copyright
Mitigation of Negative Effects of Melphalan on Cardiomyocytes with N-acetyl-L-cysteine (NAC) Treatment
Application NAC (N-acetyl-L-cystine) as an antioxidant to reduce chemotherapy induced oxidative stress and cardiotoxicity. Key Benefits Mitigates cardiotoxic side effects of alkylating agent, melphalan in human cardiomyocytes. Market Summary Melphalan is a chemotherapeutic commonly used to treat various cancers including multiple myeloma,...
Published: 7/30/2024
|
Inventor(s):
Chunhui Xu
,
Anant Mandawat
,
Rui Liu
Keywords(s):
Cardiovascular
Category(s):
TechPub Algolia > Drug Discovery
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
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Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
JobViz: User Interface for Visualization of Majors & Jobs
Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...
Published: 9/8/2022
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Inventor(s):
Deborah Silver
,
Li Liu
Keywords(s):
Category(s):
Technology Classifications > Software & Copyright
,
Technology Classifications > Software & Algorithms
Flexible and Efficient XNOR Circuit Architecture for Neural Network Based Deep Learning
Background Neuro-inspired machine deep learning have demonstrated that they can perform complex tasks such as image and speech classification, object recognition, and real-time decision-making. The state-of-the-art deep learning algorithms employ neural networks which have millions of parameters. Deploying such deep neural networks onto mobile platforms...
Published: 2/23/2023
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Inventor(s):
Shimeng Yu
,
Rui Liu
Keywords(s):
Circuits
,
Computing Architecture
,
Machine Learning
,
Memory
,
Neural Computing
Category(s):
Computing & Information Technology
,
Physical Science
,
Semiconductor Devices
,
Semiconductors, Materials & Processes
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