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Search Results - chen+xiaoyu
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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025
|
Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Yu Chen
,
Jesper Madsen
,
Steven An
Keywords(s):
Pharmaceuticals
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
LORI: Local Low-Rank Imputation for Context-Aware AI
THE CHALLENGE Leveraging Artificial Intelligence (AI) for data-driven decision-making faces a major challenge in automatically configuring and optimizing complex AI pipelines across different use cases. As organizations deal with diverse datasets and fast-changing requirements, selecting the right combination of processing steps becomes increasingly...
Published: 4/16/2025
|
Inventor(s):
Ran Jin
,
Chen Xiaoyu
Keywords(s):
Category(s):
Technology Classifications > Software
Attention-on-Attention for Human-Guided AI
THE CHALLENGE A major challenge facing industries like advanced manufacturing and quality inspection is the gap between human expertise in visual search and the limited capabilities of current AI systems. While skilled inspectors can dynamically scan, interpret, and integrate subtle visual cues over time, most existing automated solutions rely on static...
Published: 4/16/2025
|
Inventor(s):
Ran Jin
,
Chen Xiaoyu
Keywords(s):
Category(s):
Technology Classifications > Communication
,
Technology Classifications > Software
Scalable, Low Voltage Device For Liquid Crystal-Based Technologies
A multi-stable liquid crystal (LC) device based on saddle-spray director variation that enables fast optoelectronic switching and has low power requirements. Problem: LC devices are crucial for a number of modern technologies including monitors, electronic switches, and storage devices. These devices rely on an optoelectrical process by which applied...
Published: 7/30/2024
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Inventor(s):
Shu Yang
,
Yu Xia
,
Timothy Atherton
,
Douglas Cleaver
,
Andrew DeBenedictis
,
DaeSeok Kim
Keywords(s):
Optics & Photonics
Category(s):
Technology Classifications > Hardware & Components
,
Technology Classifications > Materials
PRIME: A Personalized Recommendation for Information Visualization Methods via Extended matrix Completion
Information visualization is an important mode of human-computer interaction to acquire insights of complex datasets. However, a uniform visualization format may be inefficient to bring the insights to different users at different contexts due to the users' differences in knowledge, perception, and cognition capabilities. On the other hand, typical...
Published: 10/27/2023
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Inventor(s):
Ran Jin
,
Chen Xiaoyu
,
Nathan Lau
Keywords(s):
Category(s):
Technology Classifications > Software
,
Technology Classifications > Communication
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023
|
Inventor(s):
Yu Chen
,
Michael Sacco
,
James Leahy
,
Elena Bray
,
Xingmin Sun
,
Xiujun Zhang
Keywords(s):
Drug Discovery
,
Infectious Diseases Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
|
Inventor(s):
George Sutphin
,
Samuel Freitas
,
Megha Padi
,
Chen Chen
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Biomarkers
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Screening assays
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/28/2025
|
Inventor(s):
Yu Qian
,
Yi Wang
,
Chen Chen
Keywords(s):
autonomous drone
,
flight control
,
image processing
,
railroad track inspection
,
self-navigation
Category(s):
Engineering and Physical Sciences
Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors
Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...
Published: 6/27/2024
|
Inventor(s):
Yu Chen
,
Orville Pemberton
,
Adam Renslo
,
Priyadarshini Jaishankar
Keywords(s):
Infectious Diseases Treatment
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment
Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...
Published: 6/27/2024
|
Inventor(s):
Adam Renslo
,
Derek Nichols
,
Priyadarshini Jaishankar
,
Yu Chen
,
Erica Lauterwasser
Keywords(s):
Infectious Diseases Treatment
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
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