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Search Results - hongsheng+he
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M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 8/11/2025
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Inventor(s):
Jianfeng Cai
,
Heng Liu
,
Donghui Zhu
,
Firoz Akhter
Keywords(s):
Alzheimer's Disease
,
Neurodegenerative Diseases
,
Therapeutics
Category(s):
zzNeurodegenerative Diseases Treatment
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
Human-Robot Teaming System
The Problem: Modern manufacturing and automation demand increasingly sophisticated human-robot collaboration requiring technologies that enhance human oversight and interaction with robotic systems, particularly in environments requiring meticulous quality control and error reduction. Current approaches in human-robot interaction face limitations,...
Published: 8/4/2025
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Inventor(s):
Hongsheng He
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Manufacturing
,
Technology Classifications > Systems & Services
Dynamically Controlled Pupil Steering Method for Enhanced Light Efficiency in Head-Mounted Displays
This is a programmable backlight display for head-mounted displays that dynamically steers light to the viewer’s pupil based on real-time eye tracking. This method reduces power consumption by illuminating only the necessary region corresponding to the pupil location, while also improving brightness uniformity and efficiency. It also helps mitigate...
Published: 8/4/2025
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Inventor(s):
Hong Hua
,
Pengyinjie Lyu
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Displays
,
Technology Classifications > Imaging & Optics > Lens & System Design
Fluorescence-Guided Laparoscope with Microscopic Margin Analysis Capabilities for Surgical Guidance During Tumor Resection
This technology is a laparoscope that combines both white light and fluorescence imaging (WLFI) for wide field tumor localization and multiphoton microscopy (MPM) for microscopic surgical margin definition. The WLFI channel and MPM imaging channel are housed on an extendable arm on the laparoscope and images from both channels are displayed simultaneously...
Published: 7/2/2025
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Inventor(s):
Travis Sawyer
,
Hong Hua
,
Noelle Daigle
,
Thomas Graham Knapp
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Healthcare Portfolios > General & Plastic Surgery
Overcoming Short Channel Barrier Effects of Field Effect Transistors
A design tool for overcoming short channel barrier effects of field effect transistors (FET). Background: The semiconductor industry constantly pushes innovation, demanding research and development into new materials, manufacturing processes, and designs. Silicon is the most widely used semiconductor material in the electronic industry, so there...
Published: 7/31/2025
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Inventor(s):
Hong Luo
,
Piaohan Xu
Keywords(s):
Computer
,
General Engineering
,
Instrumentation
,
Semiconductor and Microprocessing
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Computers
,
Technology Classifications > Engineering
,
Technology Classifications > Instrumentation
Quantization in Gate-All-Around Field Effect Transistors
A design for quantization of electron states in the channel of gate-all-around field-effect transistors (GAAFET). Background: The semiconductor industry constantly pushes innovation, demanding research and development into new materials, manufacturing processes, and designs. Silicon is the most widely used semiconductor material in the electronic...
Published: 7/31/2025
|
Inventor(s):
Hong Luo
,
Piaohan Xu
Keywords(s):
Featured
,
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Bioinformatics
,
Technology Classifications > Computers
,
Technology Classifications > Electronics
,
Technology Classifications > Energy
,
Technology Classifications > Instrumentation
,
Technology Classifications > Nanotechnology
System for characterizing effective permeability for oil and water in shale reservoirs
Background Accurately quantifying how oil and water move through shale is essential for optimizing energy production from unconventional reservoirs like those in the Permian Basin. These formations present significant measurement challenges due to their ultra-low permeability, variable wettability, and the presence of microfractures. Traditional methods...
Published: 5/19/2025
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Inventor(s):
Sheng Peng
Keywords(s):
Category(s):
Physical sciences > Energy > Oil & gas > Petrophysics and rock characterization
,
Physical sciences > Energy > Oil & gas > Upstream oil & gas
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025
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Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
Methods and Apparatus for Crosstalk-Free Integral Imaging Based Light Field Displays using Directional Illumination Sources
This invention presents a method and apparatus for improving integral imaging-based light field head-mounted displays (HMDs) by addressing the intrinsic crosstalk issue. Conventional integral imaging-based head-mounted displays suffer from crosstalk due to the omnidirectional emission of typical micro-display panels, which reduces image contrast and...
Published: 3/3/2025
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Inventor(s):
Hong Hua
,
Cheng-Ting Huang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Displays
,
Technology Classifications > Imaging & Optics > Lens & System Design
Novel cermet composite for nuclear waste immobilization
1.5-inch diameter cermet synthesized using hot uniaxial sintering Invention Summary: Nuclear power generates ~10% of electricity globally and ~20% in developed economies. High-level waste, expected to be produced at the back end of advanced reactor fuel cycles, includes metals, oxides, halide salts, and carbon/graphite...
Published: 8/12/2025
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Inventor(s):
Ashutosh Goel
,
John Vienna
,
John McCloy
,
S Sundaram
,
Aditya Kumar
,
Hans-Conrad zur Loye
,
Jake Amoroso
Keywords(s):
Category(s):
Technology Classifications > Energy & Battery
,
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Polymers/Composites/Materials
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