Search Results - xiaolei+wang

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Organic phosphor functionalized inorganic nanoparticle/silicone nanocomposite
RPI ID: 2013-050-403 Innovation Summary: This invention introduces phosphor-functionalized nanoparticles consisting of an inorganic nanoparticle core with long- and short-chain surface polymers and organic phosphors. The controlled grafting densities of polymers enable uniform phosphor dispersion, improving optical transparency and efficiency. The...
Published: 3/10/2026   |   Inventor(s): Brian Benicewicz, Robert, Jr. Karlicek, Ying Li, Linda Schadler Feist, Richard Siegel, Peng Tao, Lei Wang
Keywords(s):  
Category(s): Biotechnology and the Life Sciences
Novel Therapy to Prevent Kidney Transplant Rejection
Advantages First-in-class mechanism: Only known PPP1R3G/PP1γ inhibitor—differentiated from all RIPK1/RIPK3 competitors Upstream targeting: Acts before RIPK1 activation for potentially improved selectivity Validated efficacy: Demonstrated reduction in necroptosis markers (p-RIP1, p-RIP3, p-MLKL) Large unmet need: No approved DGF prevention...
Published: 2/11/2026   |   Inventor(s): Lei Wang, Zhigao Wang, Jianfeng Cai
Keywords(s): Organ Transplantation, Renal / Kidney
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics
The First Curative Treatment of Phenylketonuria Using Genetic Engineering Approaches
The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects. Problem: Phenylketonuria (PKU) is a severe disorder affecting approximately 1 in 10,000 U.S. newborns. PKU is marked by a genetic mutation in the phenylalanine hydroxylase enzyme (PAH), resulting in phenylalanine (Phe)...
Published: 2/5/2026   |   Inventor(s): Kiran Musunuru, Xiao Wang, Dominique Brooks
Keywords(s): Gene Editing, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology
Category(s): Technology Classifications > Therapeutics
LNP Delivery of Gene-Editing Machinery to Cure Hereditary Tyrosinemia Type 1g
Problem: Hereditary tyrosinemia type 1 (HT1) is a genetic metabolic disease caused by the inability to break down tyrosine, an amino acid present in many meats, dairy products, fruits, and nuts. This disease can be fatal within the first few months of life and increases the risk of liver cancer. The current treatment involves a strict drug regimen and...
Published: 8/21/2025   |   Inventor(s): Kiran Musunuru, Madelynn Whittaker, Xiao Wang, William Peranteau, Cara Berkowitz, Ana Dumitru
Keywords(s): Gene Editing, Genetic Disorders, Obesity Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Synthetic Gene Circuits
­Engineering synthetic gene circuits allows scientists to design cells to perform any number of tasks such as biosensing, therapeutic or commodity production or bioremediation to name a few. An important design principle when engineering sophisticated synthetic gene circuits is modularity as it breaks the system down into small modules, thereby...
Published: 2/26/2026   |   Inventor(s): Rong Zhang, Hanah Goetz, Juan Melendez-Alvarez, Xiao Wang, Xiaojun Tian
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Cell-permeant and water-soluble rhodamine dyes for quantitative imaging applications
Summary Rhodamines are a class of fluorescent proteins (FP) that stand out for their higher photostability and brightness as well as easier synthesis compared to other FPs; however, classic rhodamines generally have poor water solubility and tend to aggregate in an aqueous environment. Oregon Health & Science University researchers have developed...
Published: 9/21/2023   |   Inventor(s): Summer Dowell (Gibbs), Lei Wang, Antonio Montano
Keywords(s): Imaging, Imaging - Other, Research Tools, Research Tools - Reagents
Category(s): Imaging, Research Tools
A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)
Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...
Published: 2/26/2026   |   Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang
Keywords(s):  
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology
Base-Edited Isogenic hPSC Line Generation (BIG-TREE)
Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...
Published: 2/26/2026   |   Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/26/2026   |   Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Targeted Remodeling of Bacterial Genomes Using CRISPR-Nickases
Targeting DNA manipulation is integral to biotechnology and synthetic biology. Large chromosomal rearrangements and deletions have profound impacts on bacterial physiology, such as improved bioproduct levels, increased strain fitness, or changed tolerance to stress and environmental conditions. However, it requires time-consuming and laborious directed...
Published: 2/26/2026   |   Inventor(s): Xiao Wang, Kylie Standage-Beier
Keywords(s): Biological Cell Manipulation, Bio-Technology
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
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