Search Results - nicholas+brookhouser

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Resting-State Functional Magnetic Resonance Imaging Derived From Dynamic Perfusion Imaging (Case No. 2023-126)
Intro Sentence: UCLA researchers in the Department of Radiology have developed a novel method for obtaining simultaneous perfusion and functional MRI data from a single MRI acquisition to improve the diagnosis, monitoring, and management of brain tumors and stroke. Background: Advanced magnetic resonance imaging (MRI) techniques are crucial for...
Published: 8/23/2024   |   Inventor(s): Benjamin Ellingson, Nicholas Cho, Chencai Wang
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems
Base-Edited Isogenic hPSC Line Generation (BIG-TREE)
Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...
Published: 2/23/2023   |   Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Novel Cas9 Fusion (iCas9)
In recent years, the true power of predictable and high-fidelity genome engineering for applications in gene therapy and biotechnology is closer than ever to being realized, and the CRISPR and CRISPR-associated (Cas) systems have played an instrumental role in this development. While CRISPR offers great programmability, it isn’t perfect and its...
Published: 2/23/2023   |   Inventor(s): Kylie Standage-Beier, Xiao Wang, David Brafman, Nicholas Brookhouser, Parithi Balachandran
Keywords(s):  
Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Genomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices