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Search Results - hanbing+cao
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Durable cure for Pseudoxanthoma Elasticum: High-Efficiency, Precision-Targeted Gene Therapy
Lipid nanoparticles containing messenger RNA (mRNA-LNPs) encoding Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) base-editors that correct pseudoxanthoma elasticum-causing mutations. Problem: Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting approximately 1 in 25,000 Americans. It is caused by loss-of-function mutations...
Published: 6/17/2026
|
Updated: 6/17/2026
|
Inventor(s):
Xiao Wang
,
Hanbing Cao
Keywords(s):
Bioengineering
,
Cardiovascular
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Orphan Disease
Category(s):
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA. Invention Summary: Ricin toxin is lethal to human at small doses,...
Published: 2/20/2026
|
Updated: 6/10/2020
|
Inventor(s):
Nilgun Tumer
,
Xiao-Ping Li
,
Jacques Roberge
,
David Augeri
,
Bin Cao
Keywords(s):
Drug Discovery/Screening
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics