Search Results - david+brafman

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Star, Branched, and Graft Polymers in Binders for Inkjet Additive Manufacturing for Personalized Dosage Tablets
THE CHALLENGE A major problem posed by the pharmaceutical industry is giving effective dosages while not giving excessive amounts of a particular drug. An estimated 80% of side effects in humans and animals are a direct result of inaccurate dosing because varying weights in patients. Additive manufacturing has emerged as a very promising method to...
Published: 1/31/2024   |   Inventor(s): Emily Wilts, Timothy Long, Christopher Williams, Da Ma
Keywords(s):  
Category(s): Technology Classifications > Additive Manufacturing, Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Pharmacology and Therapeutics
Base-Edited Isogenic hPSC Line Generation (BIG-TREE)
Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...
Published: 2/23/2023   |   Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Novel Cas9 Fusion (iCas9)
In recent years, the true power of predictable and high-fidelity genome engineering for applications in gene therapy and biotechnology is closer than ever to being realized, and the CRISPR and CRISPR-associated (Cas) systems have played an instrumental role in this development. While CRISPR offers great programmability, it isn’t perfect and its...
Published: 2/23/2023   |   Inventor(s): Kylie Standage-Beier, Xiao Wang, David Brafman, Nicholas Brookhouser, Parithi Balachandran
Keywords(s):  
Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Genomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices