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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Combination Therapy to Treat Viral Acute Respiratory Distress Syndrome (ARDS)
­Advantages: PG’s anti-inflammatory effects mitigate viral inflammation of COVID-19. Intranasally administered mesenchymal stem cells (MSCs) create an anti-inflammatory microenvironment and can enhance neuro-regenerative effects. Targets viral transmission and neuronal damage to reduce virus-induced neuronal damage, and mortality, and...
Published: 7/15/2024   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Mahasweta Das, Andrew McGill, Karthick Mayilsamy
Keywords(s): Covid-19, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory
Methods for Treating Covid-19 Based on Individual Genomic Profiles
­Advantages: A high-throughput method offers a rapid and efficient way to predict severe outcomes in COVID-19 patients, facilitating faster clinical decision-making for pulmonary injury. Can be integrated with clinical variables to improve triage across healthcare settings, potentially reducing hospital stays, and optimizing resource allocation...
Published: 7/16/2024   |   Inventor(s): Jose Herazo-Maya, Brenda Juan-Guardela, Gaetane Michaud
Keywords(s):  
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics
AI-Driven Magnetic Respiratory Sensor for Real-Time Monitoring of Respiratory Diseases Like COVID-19
­Advantages: An AI-assisted contactless device that measures a patient’s breathing pattern and provides early and rapid detection of COVID-19 respiratory symptoms, in under 5 minutes. The ultrahigh sensitivity enables real-time monitoring of abnormal variations in a patient’s breath across multiple stages of disease. The portable...
Published: 7/15/2024   |   Inventor(s): Manh-Huong Phan, Kee Young Hwang, Valery Ortiz Jimenez, Baleeswaraiah Muchharla
Keywords(s): Artificial Intelligence, Medical Diagnostics, Respiratory Diseases
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Respiratory
Genistein For Asthma Prevention And Treatment
­Advantages: The research focuses on a tailored approach for managing asthma, specifically on individuals with high PAI-1 genotypes. The research underscores the therapeutic potential of genistein in mitigating asthma severity and associated complications. In vitro and animal data support the efficacy of genistein in reducing allergic inflammation...
Published: 4/16/2025   |   Inventor(s): Seong Cho, Raj Kumar, Brett Anderson, Michael Kaytor
Keywords(s): Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Biotechnology
Soy Isoflavones For Asthma Prevention
­Advantages: This research identified specific genetic markers (PAI-1 polymorphisms) linked to a significant reduction in asthma risk with soy isoflavone treatment. The research incorporates soy isoflavones into asthma management, leveraging the nutritional benefits of this natural compound and a holistic dietary path to respiratory wellness....
Published: 4/30/2025   |   Inventor(s): Seong Cho, Raj Kumar
Keywords(s): Genetics, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology, Technology Classifications > Electronics > Food Sciences
New natural product scaffolds with activity against respiratory syncytial virus
­Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...
Published: 7/17/2025   |   Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock
Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases
Biomarker for Chronic Lung Disease: N-Myc-Interactor (NMI)
Competitive Advantages NMI Diagnostic Biomarker: predicting chronic lung allograft dysfunction (CLAD) in lung transplant patients NMI as a novel therapeutic target, to increase its expression in chronic lung disease Summary Lung transplant remains the primary treatment option for patients with advanced lung disease or irreversible pulmonary failure....
Published: 5/20/2024   |   Inventor(s): Nirmal Sharma, Mudassir Banday, Andreas Seyfang
Keywords(s): Biomarker, Cancer Treatment Lung Cancer, Medical Diagnostics, Medical Therapeutics Gene Therapy, Therapeutics
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical
Lung Microbiome Isolation and Cultivation
­Competitive Advantages: Novel method to isolate, cultivate, and amplify the lung microbiome from a limited resource Beneficial for testing antibiotic sensitivity and drug resistance Enables lung microbiome transplantation for treatment of various chronic lung diseases Summary: Chronic lung diseases such as asthma, COPD, cystic fibrosis,...
Published: 11/25/2024   |   Inventor(s): Andreas Seyfang, Nirmal Sharma
Keywords(s): Cancer Treatment Lung Cancer, Health Tech, Microbiome
Category(s): Technology Classifications > Medical > Respiratory
Protein Palmiotylation Inhibitors of SARS Viruses
­Competitive Advantages Novel treatment for Covid-19 Inhibits palmitoylation of SARS-CoV-2 spike proteins resulting in reduced virus infectivity Inhibits syncytia formation Summary The last two decades have seen the emergence of three major corona virus(CoV) outbreaks. The SARS-CoV-2 spike glycoprotein (S) is a 1273 amino acids type I membrane...
Published: 8/8/2024   |   Inventor(s): Robert Deschenes, Arunava Roy, Ahmed Ramadan, Subhra Mohapatra, Marcello Giulianotti
Keywords(s): Cell & Tissue Culture & Engineering, Covid-19, Respiratory Diseases, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Respiratory
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