Search Results - car-t

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Improved CD22 Binders for Effective Immunotherapy Against Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
Abstract: Targeting the CD22 receptor of B-cells with chimeric antigen receptor (CAR)-T cells has been a promising new therapy to treat B-cell malignancies in clinical trials, inducing remission in 70% of patients with relapsed acute lymphoblastic leukemia (ALL). However, diminished CD22 expression on B-cell surface can lead to relapse and decreased...
Published: 8/14/2024   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Terry Fry, Sneha Ramakrishna
Keywords(s): Acute Lymphoblastic Leukemia, ALL, B Cell, CAR, CAR-T, CD22, chimeric antigen receptor, Dimitrov, T cell
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Inducing plasticity to prime immune system for CAR-Treg therapy
Project ID: D2022-28 Background Regulatory T cells (Tregs) are the critical regulators of peripheral immune tolerance; when defective, Tregs can lead to autoimmune disorders, such as Type 1 Diabetes (T1D) A more recent approach to prevent/treat autoimmunity is to refit immune cells towards their non-inflammatory phenotype in the affected organ. Chimeric...
Published: 6/18/2024   |   Inventor(s): Shahnawaz Imam, Juan Jaume
Keywords(s): CAR-T, Chimeric Antigen Receptor, EIF5A, Notch
Category(s): Cardiovascular, Renal, & Metabolism, Inflammation & Immunity