Search Results - antimicrobial

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Pranlukast for Inhibition of Oral Microbe Biofilms
Project ID:TECH2023-37 Background Streptococcus mutans is a bacterium that lives in the oral cavity of humans and is a major cause of caries, also known as dental cavities. In order to cause caries, the bacterium must form a biofilm. The biofilm creates a microenvironment in which the enamel of teeth is degraded and caries form. True anti-biofilm...
Published: 7/30/2024   |   Inventor(s): Rudolph Sloup, Jyl Matson
Keywords(s):  
Category(s): Inflammation & Immunity, Antimicrobial
Species-specific inhibitors of methionine adenosyltransferase (MAT)
Project ID: TECH2023-31 Background Drug resistance, especially to antibiotics and other antimicrobials, is a huge and growing problem. Some bacteria already have untreatable strains, and other microbes have never had good drug options. Broad-spectrum antibiotics have substantial side effects, including microbiome disruption. Cryptosporidium parvum...
Published: 5/21/2024   |   Inventor(s): Robert Blumenthal, Ronald Viola, Jacob Fries, Brandon Sharkey
Keywords(s):  
Category(s): Antimicrobial
A Parallel Droplet Microfluidic Device for Monitoring of Bacteria Culture and Multi-drug Screening
INV-17084 Background To combat antibiotic-resistant bacterial infections there is a need for rapid discovery of new antibiotic drugs. Traditionally antibiotic testing is performed by methods such as an antimicrobial susceptibility test (AST) that requires longer analysis time. New techniques such as MALDI-TOF mass spectroscopy and nucleic acid amplification...
Published: 10/15/2024   |   Inventor(s): Wenjing Kang, Tania Konry
Keywords(s):  
Category(s): -Devices, Technology Classifications > 2. Physical Science > Lab tech/equipment, Antimicrobial, Technology Classifications > 1. Life Science > Drug Discovery
New Method for Discovery of Bioactive Molecules
INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...
Published: 9/10/2024   |   Inventor(s): Slava Epstein
Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology
Category(s): -Method, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science > Drug Discovery
Oxygen Releasing Cryogels
INV-18108 Background Hydrogels have been used for several biomedical applications because of their three dimensional nature, high water content, and wide range of polymers that can be used for their fabrication. Hydrogels as 3D scaffolds have recently gained momentum because they can mimic key features of the extracellular matrix, which is mainly...
Published: 9/10/2024   |   Inventor(s): Sidi Bencherif, Thibault Colombani, Michail Sitkovsky, Adnan Memic, Stephen Hatfield
Keywords(s):  
Category(s): Technology Classifications > 1. Life Science, Antimicrobial, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Drug Delivery