Search Results - notch

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Compounds and methods to target transmembrane domain of membrane proteins (e.g., APPTM) to inhibit intramembrane proteolysis
RPI ID: 2019-075-401, 2019-076-601 Innovation Summary: A substrate-specific inhibitor is proposed to block γ-secretase cleavage of amyloid precursor protein (APP), aiming to reduce amyloid-β (Aβ) production without affecting other physiological substrates. Unlike broad-spectrum γ-secretase inhibitors that target presenilin directly,...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Chunyu Wang
Keywords(s): Alzheimer's disease, amyloid, amyloid precursor protein, anti-Abeta, C99, gamma-secretase, intramembrane proteolysis, Notch, transmembrane domain of APP
Category(s): Biotechnology and the Life Sciences
Inducing plasticity to prime immune system for CAR-Treg therapy
Project ID: D2022-28 Regulatory T cells (Tregs) are the critical regulators of peripheral immune tolerance; when defective, Tregs can lead to autoimmune disorders, such as Type 1 Diabetes (T1D) A more recent approach to prevent/treat autoimmunity is to refit immune cells towards their non-inflammatory phenotype in the affected organ. Chimeric Antigen...
Published: 4/6/2026   |   Updated: 7/3/2023   |   Inventor(s): Shahnawaz Imam, Juan Jaume
Keywords(s): CAR-T, Chimeric Antigen Receptor, EIF5A, Notch
Category(s): Cardiovascular, Renal, & Metabolism, Inflammation & Immunity