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Inducing plasticity to prime immune system for CAR-Treg therapy
Project ID: D2022-28 Background Regulatory T cells (Tregs) are the critical regulators of peripheral immune tolerance; when defective, Tregs can lead to autoimmune disorders, such as Type 1 Diabetes (T1D) A more recent approach to prevent/treat autoimmunity is to refit immune cells towards their non-inflammatory phenotype in the affected organ. Chimeric...
Published: 6/18/2024
|
Inventor(s):
Shahnawaz Imam
,
Juan Jaume
Keywords(s):
CAR-T
,
Chimeric Antigen Receptor
,
EIF5A
,
Notch
Category(s):
Cardiovascular, Renal, & Metabolism
,
Inflammation & Immunity