Vaccines have become one of the most important tools in the fight against cancers and infectious diseases. However, some vaccines have shown limitations due to their high cost and low immune responses. To overcome these limitations, bacteriophages were proposed for the development of more cost-effective, immunogenic vaccines. Phages have shown a strong ability to activate induced and adaptive immune systems. The genome of these viral particles can be engineered, and their surface proteins can be exploited for antigen display.
Researchers at National Cancer Institute (NCI) developed an engineered bacteriophage lambda () vector for displaying antigens as a vaccine in the treatment of cancer and infectious diseases. In this technology, a nucleic acid sequence encoding a fusion protein linked to a heterologous antigen is inserted into a native gene D locus adjacent to gene E in the bacteriophage lambda genome. The researchers have also constructed several phages in the λ prophage vector system to display different fusion proteins as candidate vaccines representing several human diseases like human Chronic Lymphocyte Leukemia disease and malaria.
Researchers at NCI seek licensing and/or co-development research collaborations for further development of the Bacteriophage based-vaccine system