Search Results - rama+rao+amara

7 Results Sort By:
MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara
Keywords(s): Biologic, COVID19, Immunology/Inflammation, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
Select M. tuberculosis Peptides as Mucosal Vaccines Against Pulmonary Tuberculosis
This CDC-developed technology relates to novel vaccines or boosters directed against pulmonary tuberculosis. There is currently only a single vaccine against tuberculosis, the (Bacillus Calmette-Guérin) BCG vaccine. Reports suggest widely variable effectiveness for the BCG vaccine and that BCG administration has very limited success against prevention...
Published: 7/25/2024   |   Inventor(s): Bonnie Plikaytis, Thomas Shinnick, Rama Amara, Mani Cheruvu, Suraj Sable
Keywords(s): Alaine, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DC1XXX, DC4XXX, DCXXXX, DXXXXX, Identification, Mucosal, MYCOBACTERIUM, OID-NCHHSTP-DTE, PROLINE, Pulmonary, respiratory, Respiratory Diseases, respiratory INFECTION, Rich, TUBERCULOSIS, Vaccine, VACCINE DEVELOPMENT, VJXXXX, VPXXXX, WIXXXX, WJXXXX, XCXXXX, XEXXXX, XHXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, Application > Research Materials, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Dental, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment
HIV-1 Clade C Protein Immunogen as HIV-1 Vaccine
Application Novel stabilized HIV-1 Clade C gp140 trimeric immunogen useful as a vaccine. Key Benefits Vaccine for HIV-1 infections. Induces both neutralizing and V1V2 scaffold directed antibody responses. V1V2 scaffold directed antibodies bind to multiple strains of HIV-1 from different clades including Clades B and C. Market Summary HIV-1...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara, Tiffany Styles, Anusmita Sahoo
Keywords(s): Immunology/Inflammation, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
2014-864 ApoE4-Targeted Therapeutics that Increase SIRT1
ApoE4-Targeted Theraputics That Increase SIRT1SUMMARYUCLA researchers have identified Alaproclate (A03) as a promising drug candidate to treat Mild Cognition Impairment (MCI) and Alzheimer’s disease (AD) through inhibition of the ApoE4 neurotoxicity.BACKGROUNDAlzheimer’s disease (AD) is a neurodegenerative disease whose cause is largely...
Published: 7/19/2023   |   Inventor(s): Michael Jung, Varghese John, Dale Bredesen, Barbara Jagodzinska, Jesus Campagna, Ram Rao, Johnny Pham
Keywords(s):  
Category(s): Therapeutics, Therapeutics > CNS and Neurology
Trimeric Immunogen for HIV-1 Vaccination
Application Trimeric gp120 immunogen that induces broadly cross-reactive V1V2-antibodies for HIV-1 vaccine. Key Benefits Possible oral administration. Broadly cross-reactive against HIV-1 panel. Promotes antibody responses as both a primary immunogen and boosting immunogen. Market Summary Antiretroviral therapy (ART) has dramatically prolonged...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara, Andrew Jones, Raghavan Varadarajan, Sannula Kesavardhana
Keywords(s): Antibody, Enzyme/Protein, Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
Oral Vaccine for HIV Immunization
Application Live bacteria-based vaccine that is delivered by oral route and stimulates the body's immune system to produce mucosal antibodies against HIV. Key Benefits Provides better vaccine scheme via mucosal immune response as a primary vaccine compared to other primary vaccines that are administered parenterally. Generates both antibody and...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara, June Scott, Bernard Quigley, Venkateswarlu Chamcha
Keywords(s): Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines
Novel Adjuvant for DNA-Based Vaccine
Application Adjuvant, capable of boosting the immunogenicity and effectiveness of DNA or MVA-based vaccines. Key Benefits Stimulates CD8+ (cytotoxic) T cells directly, which boosts the immune system response against infected cells. Bypasses the need for CD4+ (helper) T cells to help raise functional CD8+ T cells. Offers new therapeutic option...
Published: 7/30/2024   |   Inventor(s): Rama Rao Amara
Keywords(s): Microbiology/Infectious Diseases
Category(s): TechPub Algolia > Vaccines