Search Results - thota+ganesh

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Quinazolin-4(3H)-one Derivatives as NOX-2 Inhibitors: Composition of Matter, Methods of Preparation and Their Use
Application Quinazolin-4(3H)-one derivatives as selective NOX-2 inhibitors to prevent oxidative damage. Key Benefits Small molecule NOX-2 specific inhibitor. Prevents excessive reactive oxygen species (ROS) generation rather than removing them. Selective NOX-2 inhibition offers significant advantages to development of an effective therapy against...
Published: 3/6/2025   |   Inventor(s): Thota Ganesh, Radhika Amaradhi, Jacek Zielonka
Keywords(s): Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Alexidine and Analogs to Treat Lung Cancer
Application Small molecule therapeutic specifically targeting invasive cancer cells for treatment of lung cancer. Key Benefits Inhibits cancer cell invasion. Utilizes a novel mechanism of action. Market Summary One of the main barriers in developing new treatment strategies is the vast diversity between and within cancers. The cells within...
Published: 4/3/2025   |   Inventor(s): Adam Marcus, Jessica Konen, Rachel Commander, Jamie Arnst, Thota Ganesh
Keywords(s): Oncology Treatments, Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Novel Inhibitors of NOX2/ROS
Applications Novel therapeutics for treatment of various inflammatory airway conditions including chronic obstructive pulmonary disease (COPD). Key Benefits NOX2/ROS inhibitors have potential for use in a wide variety of clinical indications. Current treatments are weakly effective or provide only symptomatic relief for inflammatory airway diseases. Technical...
Published: 2/13/2025   |   Inventor(s): Thota Ganesh, John David Lambeth, Susan Smith, Aiming Sun
Keywords(s): Cardiovascular Treatments, Immunology and Inflammation Treatments, Metabolic Disease Treatments, Neurology and Pain Treatments, Respiratory Treatments, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics