Search Results - wei+wei

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C41 Analogs
This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 9/24/2024   |   Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics
Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat
Thermotargetron for modifying thermophilic microorganisms
The Thermotargetron is a genetic tool for modifying thermophilic micro­organisms using a type-II intron element, TeI3c‑4c. It allows efficient gene inactivation across a broad host range without needing selection markers and can target short gene sequences. Background Renewable fuels like bioethanol are increasingly vital due to rising global...
Published: 8/9/2024   |   Inventor(s): Alan Lambowitz, Georg Mohr, Wei Hong, Qui Cui, Ya-Jun Liu
Keywords(s):  
Category(s): Life sciences > Immunology > Genomics/genetics, Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Energy > Renewable
Using FDA-approved Small Molecule Drug Reserpine and related compounds (especially Halofantrine) To Protect Photoreceptors In Inherited Retinal Degenerations And Age-Related Macular Degeneration
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a therapy using an FDA-approved small molecule drug reserpine (and related compounds especially halofantrine) that prevents photoreceptor cell death in retinal degenerations. Description of Technology: Inherited Retinal Degenerations (IRD), such as Leber...
Published: 9/18/2024   |   Inventor(s): Anand Swaroop, Yu Holly Chen, Samantha Papal, Anupam Mondal, Manju Swaroop, Wei Zheng, Gregory Tawa, Wenwei Huang, Zhiji Luo
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat
3D Printed Heterogeneous Density Modulators for Enhanced Precision in Radiation Therapy
Range modulators with variable density enhancing precision to control dosage and spatial distribution of radiation. Problem: Particle radiation therapy, increasingly standard for eligible patients, requires precise energy selection to effectively target tumors. Conventional range modulators, primarily varying in thickness, lack the precision needed,...
Published: 6/12/2024   |   Inventor(s): Boon-Keng (Kevin) Teo, Peter Noel, Wei Zou, Wenbo Gu, Alexander Lin, Lei Dong, Kai Mei
Keywords(s): Oncology, Radiology
Category(s): Technology Classifications > Medical Devices
Applications of Deuterated Aldehydes and Isonitriles
This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...
Published: 6/7/2024   |   Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024   |   Inventor(s): Wei Li, Hanyu Zhu, Vincent Wang
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Knitted strain sensor for pharyngeal rehabilitation
Problem Dysphagia, or swallowing dysfunction, affects 9.5 million people in the United States. Dysphagia poses significant risks including malnutrition, dehydration, aspiration pneumonia, and death. Dysphagia is associated with diseases including stroke, muscular dystrophy, and throat cancer. The impact of dysphagia extends beyond physical discomfort,...
Published: 2/15/2024   |   Inventor(s): Jonathan Chen, James Sulzer, Corinne Jones, David Zhang, Drake Rowland, Wei Li
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Diagnostic
New Deuterated Amino Acid Derivatives
Compositions and methods of making involve the use of alternative acids as reactants instead of carboxylic acids, which produce deuterated amino acids, while carboxylic acids can only synthesize alkyl amino acids. Introducing deuterium to amino acids and derivatives improves biologically active compounds and therapeutics. Modification improves properties...
Published: 6/6/2024   |   Inventor(s): Wei Wang, Yue Dong
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Biomaterials, Technology Classifications > Life Sciences
Bioorthogonal Activation of PROTAC Prodrugs
Utilizing proteolysis targeting chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has become a potential therapeutic strategy for cancer. This innovation is an on-demand prodrug strategy called click-release proteolysis targeting chimeras, or “crPROTACs.” The crPROTACs strategy utilizes bioorthogonal chemistry and...
Published: 1/16/2024   |   Inventor(s): Wei Wang, Mengyang Chang, Giri Gnawali
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
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