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Search Results - wei+wei
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Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
,
Wenqun Zhong
,
Wei Guo
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Reconfigurable RF/Digital Hybrid 3D Interconnect
A novel interconnect technology that enables system designers to take better advantage of increased IC power while satisfying energy consumption and space limitations. Background: As the semiconductor industry develops technologies on the nano-scale, interconnect latency is increasing. This places serious limitations on designs, as the input/output...
Published: 4/1/2025
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Inventor(s):
Robert Geer
,
Wei Wang
,
Tong Jing
Keywords(s):
Technologies
Category(s):
Campus > SUNY Polytechnic Institute
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Imaging
,
Technology Classifications > Medical Imaging
,
Technology Classifications > Optics and Photonics
,
Technology Classifications > Research Tools and Reagents
Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s):
Wei Wang
,
Jennifer Carew
,
Steffan Nawrocki
,
Mengyang Chang
,
Fangchao Bi
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Oncology
,
Technology Classifications > Life Sciences > Small Molecules
Intranasally-Delivered Therapy For The Treatment Of Depression And Dementia
Intranasal nasal dantrolene nanoparticles alone, or in combination with lithium, can provide protection against depression and dementia with minimal or no side effects. Problem: Major depression disorder (MDD) affects 350 million patients in the world and about 16% of the population in USA. In addition, up to 50% of Alzheimer’s disease (AD)...
Published: 3/12/2025
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Inventor(s):
Huafeng Wei
Keywords(s):
Aging
,
Immunology
,
Immunoncology
,
Infectious Disease
,
Inflammation
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Therapeutics
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 3/12/2025
|
Inventor(s):
Huafeng Wei
,
Qing Cheng Meng
,
Ge Liang
,
Maryellen Eckenhoff
Keywords(s):
Aging
,
COVID-19
,
Nanotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Animal Health
,
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Food Science and Nutrition
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...
Published: 2/18/2025
|
Inventor(s):
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Research Tools > Reagents
Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for...
Published: 2/17/2025
|
Inventor(s):
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Research Tools > Reagents
Chip-integrated Nanolaminate Nano-optoelectrode Arrays for Interfacial Electrochemical Reaction Monitoring
THE CHALLENGE: In the field of electrochemistry, understanding the dynamics of interfacial reactions is crucial for advancements in areas such as electrocatalysis, biosensing, and energy conversion. Real-time monitoring of these reactions allows scientists to gain insights into mechanisms that drive these processes. Accurate and detailed analysis of...
Published: 4/2/2025
|
Inventor(s):
Yuming Zhao
,
Chuan Xiao
,
Wei Zhou
Keywords(s):
Category(s):
Technology Classifications > Chemicals/Materials
Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D2O
This technology presents an organophotocatalytic method for selective deuteration of metabolically labile α-positions in amides, amines, and secondary alcohols. This approach achieves high regioselectivity and deuterium incorporation by masking secondary amines as carbamates and employing a photoredox-HAT (hydrogen atom transfer) process. This...
Published: 1/21/2025
|
Inventor(s):
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Life Sciences > Therapeutics
Genetic Biomarkers for Prostate Cancer Diagnosis and Prognosis
Prostate cancer remains a significant health concern, particularly among African American men who experience higher incidence of prostate cancer as well as more aggressive forms of the disease. The identification of reliable biomarkers is crucial for early detection, assessing the risk of developing the disease, determining its aggressiveness, and predicting...
Published: 2/18/2025
|
Inventor(s):
Bi-Dar Wang
,
Norman Lee
,
Jennifer Freedman
,
Yanru Wang
,
Hongliang Liu
,
Qingyi Wei
,
Daniel George
,
Steven Patierno
Keywords(s):
Category(s):
Technology Classifications > Diagnostics > Biomarkers
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