Search Results - zhengrong+cui

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Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery
Spray-dried RNA-lipid nanoparticle dry powder technology for stable and inhalable delivery of therapeutics
Background Messenger RNA (mRNA) therapeutics have rapidly emerged as a transformative method for vaccination and gene therapy. However, the field faces significant hurdles related to the instability of mRNA molecules, which are highly susceptible to enzymatic degradation. Lipid nanoparticles (LNPs) have become the delivery vehicle of choice, shielding...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Bhupendra Giri, Hugh Smyth
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Dry powder cell formulations for long-term viability and therapeutic applications
This technology stabilizes eukaryotic cells by mixing them with sugars, antioxidants, polymers, and optionally proteins, then rapidly freezing and freeze-drying them to create a dry powder that maintains high cell viability for long-term storage. Background The field of biopreservation and cell therapy is fundamentally challenged by the need to maintain...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Mahmoud Hanafy, Robert Williams
Keywords(s):  
Category(s): Life sciences > Research tools
Thin film freezing technology for stable dry formulations of mRNA therapeutics
A thin film freezing method transforms mRNA and lipid nanoparticles into stable dry powders that retain their effectiveness and size. This eliminates the need for ultra-cold storage, allowing the powders to be inhaled or reconstituted, improving the distribution of mRNA therapies. Background mRNA therapeutics represent a groundbreaking advancement...
Published: 1/13/2026   |   Inventor(s): Robert Williams, Chaeho Moon, Sawittree Sahakijpijarn, Haiyue Xu, Zhengrong Cui
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Drug delivery
Layered simulation software for optimizing freeze-drying of porous particle beds
Background Freeze-drying is a critical process in pharmaceutical, nutraceutical, and food manufacturing where product stability and preservation are paramount. Despite its widespread use, traditional freeze-drying remains inefficient, requiring long cycle times and high energy input. These limitations become even more pronounced during scale-up, where...
Published: 1/21/2026   |   Inventor(s): Zhengrong Cui, Benjamin Southard
Keywords(s):  
Category(s): Life sciences > Medical technology > TechBio (software innovation in healthcare), Life sciences > Therapeutics > Manufacturing platform
Nanoparticle technology for sustained release of therapeutic agents
This invention describes lipid-based nanoparticles designed for encapsulating and slowly releasing therapeutic agents, such as siRNA, to treat diseases. These nanoparticles enhance drug delivery efficiency and minimize rapid release, improving treatment outcomes and reducing side effects. Background Chronic inflammation-related diseases, such as rheumatoid...
Published: 1/13/2026   |   Inventor(s): Zhengrong Cui, Abdulaziz Aldayel
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Small molecule
A pharmaceutical compound for targeted cancer therapy using nucleobase analog derivatives with omega-3 fatty acids
The invention describes compounds combining nucleobase analogs with omega-3 fatty acids, enhancing cancer treatment efficacy, particularly for pancreatic cancer. These compounds improve stability and solubility and demonstrate significant anti-cancer activity, offering potential for targeted therapy. Background Pancreatic cancer presents a significant...
Published: 1/13/2026   |   Inventor(s): Zhengrong Cui, Dharmika Lansakara
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Therapeutics > Biologic