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Search Results - chengyue+wu
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High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025
|
Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Yu Chen
,
Jesper Madsen
,
Steven An
Keywords(s):
Pharmaceuticals
,
Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
Deep learning quantitative MRI platform for predicting breast cancer treatment response
Background Despite major advancements in quantitative medical imaging, accurately forecasting patient-specific treatment outcomes remains a critical unmet need—especially in oncology, where early insights into therapeutic efficacy can profoundly impact survival. The complexity of cancer progression and variability among individuals challenge...
Published: 5/2/2025
|
Inventor(s):
Thomas Yankeelov
,
Casey Stowers
,
Chengyue Wu
,
Jonathan Tamir
,
Sidharth Kumar
,
Gaiane Rauch
,
Caroline Chung
Keywords(s):
Category(s):
Life sciences > Medical technology > TechBio (software innovation in healthcare)
Predicting breast cancer response to therapy with MRI and modeling
Background/problem Neoadjuvant therapy (NAT) for cancer treatment is currently based on generalized population-based data such as receptor status, tumor grade, body surface area, and genetic markers. This approach is inherently limited, as it does not account for the unique spatial and physiological characteristics of individual tumors. Consequently,...
Published: 5/2/2025
|
Inventor(s):
Thomas Yankeelov
,
Angela Jarrett
,
David Hormuth
,
Anum Kazerouni
,
Chengyue Wu
,
Stephanie Barnes
,
Gaiane Rauch
,
Caroline Chung
Keywords(s):
Category(s):
Life sciences > Imaging
,
Life sciences > Diagnostic
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023
|
Inventor(s):
Yu Chen
,
Michael Sacco
,
James Leahy
,
Elena Bray
,
Xingmin Sun
,
Xiujun Zhang
Keywords(s):
Drug Discovery
,
Infectious Diseases Treatment
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Medical Diagnostics
,
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical > Biotechnology
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 1/31/2025
|
Inventor(s):
Ada Poon
,
Cheng Chen
,
Joonseok Yang
,
Hui Wang
Keywords(s):
EEG
,
Neurology
,
Wearable
Category(s):
Technology Classifications > Engineering
Quick, Reversible, Moisture-Activated Adhesive
Activated by water quickly, dry hydrogel film adhesive produces a strong and reversible adhesion. Problem: Adhesives are used in numerous applications in our daily lives. In general, adhesives are either strong but irreversible or weak but reversible. There is a need for stronger and reversible adhesives. One potential solution is a formulation of...
Published: 10/16/2023
|
Inventor(s):
Shu Yang
,
Mingtao Chen
,
Alexander Tucker
,
Anand Jagota
,
Yue Wu
Keywords(s):
Hydrogels
,
Surgery
Category(s):
Technology Classifications > Medical Devices
,
Technology Classifications > Materials
New MRI acquisition and post-processing technique for improved breast cancer diagnosis
New computational imaging platform can improve patient-specific characterization of breast cancerProblemClinicians rely on imaging to direct the path of treatment for breast cancer. The current standards for vascular imaging, MRI and CT, can miss valuable information. Fortunately, there has been a wave of technical progress with digital health technologies....
Published: 11/5/2024
|
Inventor(s):
Thomas Yankeelov
,
Chengyue Wu
,
David Hormuth
,
Todd Oliver
,
Robert Moser
,
Greg Karczmar
,
Federico Pineda
,
Ty Easley
,
Rina Barber
,
Boyl Kim
,
Deepa Sheth
,
Aytek Oto
,
Hiroyuki Abe
,
Milica Medved
,
Xiaobing Fan
,
Aritrick Chatterjee
,
Shiyang Wang
Keywords(s):
Cancer
,
Diagnostics
,
Imaging
,
Magnetic resonance imaging
,
Medical imaging
,
MRI
Category(s):
Life sciences > Medical technology > TechBio (software innovation in healthcare)
,
Life sciences > Diagnostic
,
Software > Digital health
Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
|
Inventor(s):
George Sutphin
,
Samuel Freitas
,
Megha Padi
,
Chen Chen
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Biomarkers
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Screening assays
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/28/2025
|
Inventor(s):
Yu Qian
,
Yi Wang
,
Chen Chen
Keywords(s):
autonomous drone
,
flight control
,
image processing
,
railroad track inspection
,
self-navigation
Category(s):
Engineering and Physical Sciences
Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors
Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...
Published: 6/27/2024
|
Inventor(s):
Yu Chen
,
Orville Pemberton
,
Adam Renslo
,
Priyadarshini Jaishankar
Keywords(s):
Infectious Diseases Treatment
,
Pharmaceuticals
Category(s):
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical
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