Ion-Doped Supramolecular Nanostructures

NU 2023-006

INVENTORS

• Samuel Stupp*
• Zaida Alvarez Pinto
• Ivan Ramos Sasselli
• Nicholas Allen Sather
• Zois Syrgiannis

SHORT DESCRIPTION

This technology involves the development of ion-doped peptide amphiphiles (IDPAs) that form supramolecular nanostructures capable of enhancing neural development and membrane excitability through dense ion cloud generation.

BACKGROUND

Ion transport and storage are pivotal in both energy systems and biological functions, particularly in the central nervous system (CNS). Traditional approaches to control ion flow in the CNS involve synthetic molecules that often face limitations in ion transfer efficiency. The need for advanced materials that can effectively manipulate ion transport dynamics is critical, especially for addressing channelopathies and enhancing neuronal functions.

ABSTRACT   

The invention presents a novel functional material created by co-assembling anionic peptide amphiphiles with small organic cations, resulting in ion-doped peptide amphiphiles (IDPAs). These IDPAs form nanostructures with a higher degree of ionization compared to traditional peptide amphiphile fibrils. The IDPA scaffolds generate dense ion clouds that stimulate neuronal gene expression, offering potential as regenerative therapies. This innovative approach not only elucidates ion transfer mechanisms but also enhances neural development and membrane excitability, showcasing significant promise in therapeutic applications.

APPLICATIONS

• Regenerative Therapies
  • Enhances neural development and membrane excitability.
• Ion Transfer Mechanism Studies
  • Provides insights into ion transfer dynamics in biological systems.
• Therapeutic Strategies for Channelopathies
  • Offers potential solutions for conditions caused by compromised ion channel functions.

• Enhanced Ionization
  • IDPA nanostructures exhibit a higher degree of ionization than traditional materials.
• Dense Ion Cloud Generation
  • Facilitates the creation of dense ion clouds that stimulate neuronal gene expression.
• Potential for Regenerative Therapies
  • Offers unique molecular mechanisms for enhancing neural development.

IP STATUS

• PCT Patent Application Filed