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Search Results - yanchao+zhang
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Viral-Targeted Nanostructured Drug (VTND) Platform
The outbreak of COVID-19 and subsequent mutant variants has caused millions of deaths and severe acute respiratory illness worldwide. Therapeutics such as monoclonal antibodies, small molecule drugs inhibiting viral replication and immune modulators suppressing hyperinflammation have shown promise, but each comes with limitations including viral variant...
Published: 11/21/2023
|
Inventor(s):
Hao Yan
,
Yang Xu
,
Deeksha Satyabola
,
Yize (Henry) Li
,
Abhay Prasad
Keywords(s):
Category(s):
COVID-19
,
SARS-CoV-2
,
Coronavirus
,
Advanced Materials/Nanotechnology
,
Life Science (All LS Techs)
,
Pharmaceuticals
,
Non-Cancer Therapeutics
Label-Free Detection Platform for CircRNAs
Circular RNAs (circRNAs) hold great potential as novel biological and clinical biomarkers for diagnosis and prognosis of cancer and other diseases. Conventional detection techniques such as northern blotting, microarray, qRT-PCR and RNA-seq suffer from many issues including low sensitivity and background noise, which limit the use of circRNA in clinical...
Published: 1/19/2024
|
Inventor(s):
Hao Yan
,
Yang Xu
,
Shaopeng Wang
,
Zijian Wan
,
Liangxiao Chen
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Medical Diagnostics/Sensors
,
Imaging
,
Advanced Materials/Nanotechnology
,
Biomaterials
,
Bioanalytical Assays, Chemistries & Devices
,
Cancer
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. <.HDBackground>Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases,...
Published: 1/29/2024
|
Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Structure Assisted Directed Evolution of Multivalent Ligands
Nanotechnology needs organization and precise control, which is why DNA self-assembly into nanostructures has been a remarkable breakthrough. The challenges in creating nanostructures and also the opportunities lie in how to achieve self-sustained replication. This allows for the system to amplify itself in unlimited cycles, which is not enabled in...
Published: 9/20/2024
|
Inventor(s):
Hao Yan
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Bioanalytical Assays, Chemistries & Devices
,
Diagnostic Assays/Devices
,
Life Science (All LS Techs)
,
Genomic Assays/Reagents/Tools
DNA Gridiron
Self-assembling nucleic acid molecules have been utilized extensively for constructing unique nanoscale structures, and designing increasingly complex structures is a top nanotechnology challenge. Current methods to create NDA nanostructures are restricted to discrete domains of parallel lines as a result of the double crossover based unit motif, which...
Published: 4/14/2023
|
Inventor(s):
Dongran Han
,
Hao Yan
Keywords(s):
DNA nanotechnology
Category(s):
Advanced Materials/Nanotechnology
,
Life Science (All LS Techs)
,
Biomaterials
,
Chemical/Biological Sensors
,
Genomic Assays/Reagents/Tools
Tumor-Targeted Killing with Aptamer-Nucleic Acid Nanostructures
Despite decades of research, cancer remains one of today’s most pressing health concerns. Traditional treatment approaches such as radiation therapy and chemotherapy can cause systemic toxicity and become ineffective when resistant tumors emerge. Recently, anticancer strategies have focused on drugs which specifically target tumor-related biological...
Published: 4/14/2023
|
Inventor(s):
Yung Chang
,
Hao Yan
Keywords(s):
Bio-Technology
,
Drug Screening
,
Therapeutics
Category(s):
Life Science (All LS Techs)
,
Cancer Therapeutics
,
Genomic Assays/Reagents/Tools
Creation of Multivalent Aptamers to Target Effector T Cells to Attack Tumor Cells
Despite decades of research effort, cancer remains one of today’s most pressing health concerns. Present day treatment methods tend to include debilitating side effects mainly due to low specificity of the treatments. Recently, some attempts have been made to augment tumor immunity by using bi-specific, hybrid antibodies that direct immune cells...
Published: 4/14/2023
|
Inventor(s):
Yung Chang
,
Hao Yan
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Cancer Therapeutics
,
Genomic Assays/Reagents/Tools
,
Pharmaceuticals
Authenticating a User on a Mobile Device
Protecting mobile devices from unauthorized access is becoming more than indispensable these days. In particular, mobile devices such as smartphones and tablets are pervasive and store increasingly highly sensitive information about a user (e.g., contacts, usernames, passwords, emails, browser histories, business secrets, health conditions, etc.)....
Published: 2/27/2023
|
Inventor(s):
Yimin Chen
,
Yanchao Zhang
Keywords(s):
Authentication
,
Detection
,
Mobile technology
,
Recognition imaging
,
Security
,
Transactions Security
Category(s):
Computing & Information Technology
,
Physical Science
,
Intelligence & Security
Secure Zero-Effort Two-Factor Authentication for Mobile Devices
Mobile two-factor authentication (2FA) has become common for user verification and secure sign-in. Mobile 2FA adds a smartphone or other mobile device as a second layer of security for accessing online accounts, in addition to the traditional username and password. After a user enters a username and matching password, the online system will grant access...
Published: 10/3/2023
|
Inventor(s):
Yanchao Zhang
,
Dianqi Han
Keywords(s):
Category(s):
Wireless & Networking
,
Physical Science
,
Intelligence & Security
,
Computing & Information Technology
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
|
Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
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