Search Results - compounds

11 Results Sort By:
Repurposed Use of the Alkaloids Emetine and Cephaeline to Treat Zika Virus Infection
This technology includes the use of two related compounds, Emetine and Cephaeline, as a potent inhibitor of the Zika virus (ZIKV). Emetine and it's analog Cephaeline were identified in a high-throughput assay aimed at identifying anti-ZIKV compounds. Both Emetine and Cephaeline are potent inhibitors of ZIKV infection in cell culture, and Emeline is...
Published: 7/25/2024   |   Inventor(s): Emily Lee, Wei Zheng, Miao Xu, Ruili Huang, Shu Yang, Wenwei Huang, Khalida Shamim, Hao Li, Hengli Tang
Keywords(s): compounds, Emetine, Flavivirus, Infection, Prevention, treatment, VLXXXX, WIXXXX, WKXXXX
Category(s): Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Research Materials
Identification and Use of Heterocyclic Alcohol Compounds for the Treatment of SULT1A1-expressing Cancers
This technology includes the identification and use of heterocyclic alcohol compounds, including RITA and N-BIC, for the treatment of SULT1A1-expression cancers. A high-throughput screen (qHTS) was performed using >1,000 caner cell lines identified a compound called YC-1 (also called Lificiguat) that is effective across cancer cell types that express...
Published: 7/25/2024   |   Inventor(s): Min Shen, Ke Kong, Toble Lee, Samarjit Patnaik, Olivia Lee, Jonathan Shrimp, Mindy Davis, Juan Marugan, Wei Zhao, Matthew Hall
Keywords(s): Agents, Alcohol, anti-cancer, Class, compounds, HETEROCYCLIC, SULT1A1-dependent, VCXXXX, WKXXXX, XCXXXX, XEXXXX
Category(s): Application > Research Materials, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Oncology
Heterocyclic Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that have changed the HCV treatment paradigm. However, the...
Published: 7/25/2024   |   Inventor(s): Zongyi Hu, Juan Marugan, Noel Southall, Xin Hu, Jingbo Xiao, Shanshan (Melissa) He, Marc Ferrer-Alegre, Wei Zheng, Kevin Frankowski, Frank Schoenen, Kelin Li, Tsanyang (Jake) Liang
Keywords(s): C, Class, compounds, DB4BXX, Development, Hepatitis, Novel, treatment, VLXXXX, WKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Novel Small Molecule Antimalarials for Elimination of Malaria Transmission
The transmission of malaria begins with injection of sporozoites into a human from the bite of a female anopheles mosquito, which initiates the malarial life cycle in humans. When a mosquito bites an infected human, the ingested male and female malaria gametocytes fuse to form a zygote that eventually becomes an oocyst. Each oocyst produces thousands...
Published: 7/25/2024   |   Inventor(s): Wei Zheng, Seameen Dehdashti, Noel Southall, Wenwei Huang, Wei Sun, Takeshi Tanaka, John McKew
Keywords(s): compounds, DB2XXX, Gametocytocidal, Identification, Malaria, Novel, VOXXXX, WKXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products
Methods of Treating Giardiasis Using FDA-Approved Compounds
This technology includes a group of at least twenty-nine, diverse, commercially available compounds that are newly identified for activity against Giardia lamblia parasites. At least six of the candidate compounds, Bortezomib, Decitabine, Hydroxocobalamin, Amlexanox, Idarubicin, and Auranofin have preexisting FDA approval for human use for other (non-Giardia)...
Published: 7/25/2024   |   Inventor(s): Catherine Chen, Juan Marugan, Noel Southall, Christopher Austin, Osnat Herzberg, Andrey Galkin, Wei Zheng
Keywords(s): compounds, DB2XXX, DBXXXX, DXXXXX, Giardiasis, NCTT, Novel, treatment
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease
Novel dopamine D2 receptor ligands for Parkinson’s disease & schizophrenia
Dopamine is a catecholamine neurotransmitter that mediates physiological functions in the central and peripheral nervous systems. Binding of dopamine to the dopamine D2 receptor elicits intracellular signaling implicated in various neurological disorders such as Parkinson’s disease (PD) and schizophrenia. Drugs targeting the dopamine D2 receptor...
Published: 3/4/2024   |   Inventor(s): Thomas Keck, Chun Wu
Keywords(s): Compounds, Dopamine D2, Neurological, Parkinson Disease, Schizophrenia, Therapeutic, Treatment
Category(s): Human Health Care > Therapeutics
Phenolic Epoxy Methacrylate Monomers Derived from Renewable Sources and Their Method of Preparation
TechnologyBisphenol-A is a chemical produced in large quantities since the 1960s for use primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics and epoxy resins are used in a number of applications including food and drink packaging and to coat products, respectively. In 2010, the United States Food and Drug Administration...
Published: 2/14/2024   |   Inventor(s): Joseph Stanzione, Alexander Bassett, John La Scala
Keywords(s): Biomaterials, Compounds, Manufacturing , Plastics, Polymers, Resin
Category(s): Engineering > Materials
Antibacterial and Antifungal Disinfecting Agents that Rapidly Kill Antibiotic-Resistant Bacteria
High-Potency Synthetic Compounds to Eradicate Biofilms and Kill Fungal Cells and Persister Cells Such as MRSA, MRSE, and VREThese superior, highly potent N-Arylated NH125 analogues demonstrate broad-spectrum antibacterial activities against even drug-resistant strains and are promising agents for disinfectants and antiseptics that eradicate bacteria,...
Published: 6/27/2021   |   Inventor(s): Robert Huigens, Yasmeen Abouelhassan, Akash Basak
Keywords(s): Antibacterial, antibacterials, biofilm eradicating agent, Compounds, Disinfectant, N-arylated NH125 analogues, persister cell killer
Category(s): Technology Classifications > Human Health Care > Therapeutics
Targeting Podoplanin to Combat Cancer
Sentrimed® is launching its first product, MASL®, to treat and prevent cancer and arthritis. Our technology is protected by issued patents and proprietary technology tailored to combat cancer and inflammatory diseases by targeting a unique receptor, called podoplanin (PDPN), which is expressed by cancer and inflammatory cells. We have received...
Published: 2/16/2024   |   Inventor(s): Gary Goldberg, Yongquan Shen
Keywords(s): Cancer, Compounds, Therapeutic
Category(s): Human Health Care > Therapeutics
Bio-based Phenolic-containing Polymers
TechnologyBisphenol-A is a chemical produced in large quantities since the 1960s for use primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics and epoxy resins are used in a number of applications including food and drink packaging and to coat products, respectively. In 2010, the United States Food and Drug Administration...
Published: 2/14/2024   |   Inventor(s): Craig Paquette, John La Scala, Joshua Sadler, Alexander Bassett, Joseph Stanzione, Palmese Giuseppe
Keywords(s): Biomaterials, Compounds, Manufacturing , Plastics, Polymers, Resin
Category(s): Engineering > Materials
1 2