Search Results - xin+xu

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D3-Selective Dopamine Agonist Platform: Eliminating D2-Mediated Side Effects in Parkinson’s and Movement Disorders
Every major dopaminergic therapy on the market today shares the same fundamental limitation: it cannot distinguish between two closely related receptor subtypes (D2 and D3). This technology changes that. We have discovered and optimized a novel small molecule, ML417, that selectively activates the D3 dopamine receptor while leaving its close cousin,...
Published: 8/4/2026   |   Updated: 8/4/2026   |   Inventor(s): David Sibley, Juan Marugan, Benjamin Free, Amy Moritz, Jeffrey Aube, Joseph Steiner, Kevin Frankowski, Marc Ferrer-Alegre, Noel Southall, Xin Xu, Warren Weiner
Keywords(s):  
Category(s): TherapeuticArea > Neurology, Application > Therapeutics
Discovery of potent and selective D3 antagonist with alleviated hERG liability and optimized pharmacokinetic properties
One of the most challenging hurdles in creating safe and effective new medicines for many diseases is finding drugs that are effective without causing off-target cardiac issues, such as cardiac arrythmias. In collaboration with NIDA, scientists at NCATS have developed a series of novel and highly specific dopamine D3 receptor agonists and antagonists...
Published: 11/14/2025   |   Updated: 6/13/2025   |   Inventor(s): Khalida Shamim, Wenwei Huang, Wei Zheng, Catherine Chen, Xiuli Huang, Xin Hu, Xin Xu, Pranav Shah, Elias Padilha, Philip Sanderson, Amy Newman
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health
Non-invasive melanoma thickness measurement
PAGE TITLEOverviewPAGE SUMMARY Melanoma is a malignant tumor of melanocytes, which are melanin-producing cells located predominately in the skin. Melanoma is one of the most aggressive and deadly types of cancer. Approximately 80,000 new cases of invasive melanoma are diagnosed in the United States, and about 10,000 people die of the disease annually....
Published: 2/12/2026   |   Updated: 9/11/2017   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics
Rapid Antimicrobial Susceptibility Testing using Piezoelectric Sensor
PAGE TITLE Overview PAGE SUMMARY In the U.S., each year at least 2 million people acquire serious infections with bacteria resistant to one or more of the antibiotics, resulting in >$20 billion in direct healthcare costs and $35 billion in lost productivity. In particular, nosocomial bloodstream infections (BSI’s), including catheter-related...
Published: 2/12/2026   |   Updated: 8/7/2017   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu, Christopher Emery, Suresh Joshi, Wei Wu
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Advanced Materials & Chemicals