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Search Results - inhibiting
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Novel ACRV1/ALK2 Inhibitors and Methods for
Inhibiting
BMP Signaling for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
This technology includes the identification and use of novel ACRV1/ALK2 inhibitors for the treatment of fibrodysplasia ossificans progressiva (FOP), an autosomal-dominant rare disease that affects one person in every 1-2 million. FOP is characterized by malformation of the great (big) toes during embryonic development and by progressive heterotopic...
Published: 10/28/2024
|
Inventor(s):
Jian-kang Jiang
,
Khalida Shamim
,
Philip Sanderson
,
Wei Zheng
,
Xiuli Huang
,
Gregory Tawa
,
Asaf Alimardanov
,
Arthur Lee
,
Junfeng Huang
,
Wenwei Huang
Keywords(s):
ALK2
,
BMP
,
INHIBITING
,
Inhibitors
,
Methods
,
Novel
,
SIGNALING
,
VGXXXX
,
WIXXXX
,
WKXXXX
,
XEXXXX
Category(s):
TherapeuticArea > Endocrinology
,
Application > Therapeutics
,
Application > Research Materials
Pyrophosphate Analog HIV-1 Reverse Transcriptase Inhibitors
The invention relates to compounds that inhibit HIV-1 DNA synthesis mediated by reverse transcriptase (RT). HIV-1 DNA synthesis by RT utilizes deoxynucleoside 5’-triphosphate (dNTP) as substrate and like many other enzymes, the reaction is reversible. Pyrophosphate analogs like imidodiphosphate strongly promote reverse reaction dNTP products containing...
Published: 10/28/2024
|
Inventor(s):
William (Bill) Beard
,
David Shock
,
Samuel Wilson
Keywords(s):
DB4AXX
,
HIV-1
,
INHIBITING
,
PYROPHOSPHATE
,
TRANSCRIPTASE
,
VLXXXX
,
YBXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease