Search Results - srinivas+tipparaju

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Advantages: A new Kcnab2 exon 4-floxed mice, suitable for experimental models to study muscle development, regeneration, and pathogenesis. Kcnab2 exon 4-floxed mice were successfully generated using CRISPR/Case9 technology. Allows for specific study of the Kcanb2 function on skeletal muscle (e.g. TA) without significant changes in the brain...

Published: 9/20/2024 | Inventor(s): Srinivas Tipparaju

Keywords(s): Animal Models, Cardiological Diseases Treatment, Cardiovascular Diseases

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Cell & Tissue Engineering

Novel Nampt Activators and Synthesis Method for Cardiovascular and Aging-Related Diseases

Advantages: 2-Aminothiazole scaffold compounds are synthesized in aqueous condition, a practical and green approach. 3-component one-pot synthesis route with high reaction yield, shorter reaction time, and mild reaction conditions. Compounds are non-cytotoxic Nampt activators effective in promoting in vitro wound closure. Potential treatment...

Published: 7/23/2024 | Inventor(s): Kirpal Bisht, Srinivas Tipparaju

Keywords(s):

Category(s): zzCardiology, Technology Classifications > Medical > Pharmaceuticals

Ophthalmological Formulations for the Prevention of a Coronavirus Infection

Advantages: Directly delivers remdesivir in ophthalmic drops to the eye cells potentially minimizing systemic side effects. Formulation is designed to prevent disease transmission via the eyes and to treat conjunctivitis caused by infection. Nanoparticulate formulation meets pharmaceutical delivery standards. Summary: COVID-19, caused...

Published: 7/17/2024 | Inventor(s): Vijaykumar Sutariya, Srinivas Tipparaju, Kevin Sneed, Manas Biswal, Ozlem Guzeloglu-Kayisli, Ramesh Ayyala, Radouil Tzekov

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Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Medical Diagnostics

Targeting Cellular Senescence by PD-L1 Binding Peptide Engineered Extracellular Vesicles

Advantages: Engineered extracellular vesicles (EVs) by surface modification with PD-L1 binding peptide and PEGylation to target senescent VSMCs. Promising novel interventions for age-related and vascular diseases. Efficacy: Proven uptake of modified EVs in the aorta of old mice and senescent VSMCs. Summary: Targeting senescent cells, particularly...

Published: 8/22/2024 | Inventor(s): Wanling Xuan, Srinivas Tipparaju, Vijaykumar Sutariya

Keywords(s): Drug Delivery and Nanomedicine, Genetics, Peptides

Category(s): Technology Classifications > Medical > Medical Nanotechnology, Technology Classifications > Medical > Biotechnology

Cardioprotective Activity of Nampt Activator in Diabetic Mice

Competitive Advantages Increased cardio protection Provides improved glucose tolerance An anti-diabetic agent Safe for long term use Summary USF researchers have investigated a novel pharmaceutical compound, known as P7C3. This compound was found to be a nicotinamide phosporiibosyltransferese (Nampt) activator and exhibited...

Published: 8/25/2023 | Inventor(s): Srinivas Tipparaju, Jared Tur, Kalyan Chapalamadugu, Sachin Badole

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Category(s): Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical